Patients With Grade 3 and 4 Clinical Adverse Experience by Dose Group Possibly Related to DAB389IL-2 Administration
| . | 3-9 (n = 19) No. (%) . | 12-15 (n = 18) No. (%) . | 19 (n = 18) No. (%) . | 23-27 (n = 13) No. (%) . | 31 (n = 5) No. (%) . |
|---|---|---|---|---|---|
| Fever/chills | 1 (5) | — | 1 (6) | 2 (16) | 1 (20) |
| Nausea/vomiting | 1 (5) | — | — | 2 (16) | 1 (20) |
| Asthenia | — | — | 1 (6) | 3 (23) | 3 (60) |
| Hypotension | — | — | 2 (11) | 1 (8) | — |
| Edema | — | — | 1 (6) | 1 (8) | — |
| Pain | — | — | 1 (6) | 1 (8) | — |
| Infection | 1 (5) | — | 1 (6) | — | — |
| Rash | 1 (5) | — | 1 (6) | — | 1 (20) |
| Anorexia | — | 1 (6) | — | 2 (16) | 1 (20) |
| Headache | — | — | 1 (6) | — | — |
| Pruritus | — | — | — | 1 (8) | — |
| Weight loss | — | — | — | 1 (8) | — |
| Malaise | — | — | — | — | 2 (40) |
| Chest tightening | — | 1 (6) | — | — | — |
| Dyspnea | 1 (5) | 1 (6) | 1 (6) | — | 1 (20) |
| Dehydration | — | 1 (6) | — | 2 (16) | — |
| Allergic reaction | — | — | 1 (6) | — | — |
| Anaphylaxis | — | — | 1 (6) | — | — |
| Atrial fib | 1 (5) | — | — | — | — |
| Muscle spasm | — | 1 (6) | 1 (6) | — | — |
| Respiratory symptoms | 1 (5) | — | — | — | — |
| Sweating | — | — | 1 (6) | — | — |
| . | 3-9 (n = 19) No. (%) . | 12-15 (n = 18) No. (%) . | 19 (n = 18) No. (%) . | 23-27 (n = 13) No. (%) . | 31 (n = 5) No. (%) . |
|---|---|---|---|---|---|
| Fever/chills | 1 (5) | — | 1 (6) | 2 (16) | 1 (20) |
| Nausea/vomiting | 1 (5) | — | — | 2 (16) | 1 (20) |
| Asthenia | — | — | 1 (6) | 3 (23) | 3 (60) |
| Hypotension | — | — | 2 (11) | 1 (8) | — |
| Edema | — | — | 1 (6) | 1 (8) | — |
| Pain | — | — | 1 (6) | 1 (8) | — |
| Infection | 1 (5) | — | 1 (6) | — | — |
| Rash | 1 (5) | — | 1 (6) | — | 1 (20) |
| Anorexia | — | 1 (6) | — | 2 (16) | 1 (20) |
| Headache | — | — | 1 (6) | — | — |
| Pruritus | — | — | — | 1 (8) | — |
| Weight loss | — | — | — | 1 (8) | — |
| Malaise | — | — | — | — | 2 (40) |
| Chest tightening | — | 1 (6) | — | — | — |
| Dyspnea | 1 (5) | 1 (6) | 1 (6) | — | 1 (20) |
| Dehydration | — | 1 (6) | — | 2 (16) | — |
| Allergic reaction | — | — | 1 (6) | — | — |
| Anaphylaxis | — | — | 1 (6) | — | — |
| Atrial fib | 1 (5) | — | — | — | — |
| Muscle spasm | — | 1 (6) | 1 (6) | — | — |
| Respiratory symptoms | 1 (5) | — | — | — | — |
| Sweating | — | — | 1 (6) | — | — |