In Vivo Hematopoietic Effects of KL and FL
| Cell Type . | Response . | KL . | FL . |
|---|---|---|---|
| LTRC | Expansion | + | + |
| Mobilization | + | + | |
| Primitive/committed progenitors | Expansion Mobilization | + + | + + |
| Red blood cells | Reticulocytes | +/NE | ND |
| Hematocrit | +/NE | Reduced | |
| Platelets | Megakaryocytes | +/NE | ND |
| Platelets | +/NE | ND | |
| White blood cells | Total number | + | + |
| Granulocytes | + | + | |
| Monocytes | +/NE | + | |
| Lymphocytes | +/NE | + | |
| Mast cells | Number | + | NE |
| Activation | + | NE | |
| Dendritic cells | Number | NE | + |
| Cell Type . | Response . | KL . | FL . |
|---|---|---|---|
| LTRC | Expansion | + | + |
| Mobilization | + | + | |
| Primitive/committed progenitors | Expansion Mobilization | + + | + + |
| Red blood cells | Reticulocytes | +/NE | ND |
| Hematocrit | +/NE | Reduced | |
| Platelets | Megakaryocytes | +/NE | ND |
| Platelets | +/NE | ND | |
| White blood cells | Total number | + | + |
| Granulocytes | + | + | |
| Monocytes | +/NE | + | |
| Lymphocytes | +/NE | + | |
| Mast cells | Number | + | NE |
| Activation | + | NE | |
| Dendritic cells | Number | NE | + |
The table is based on the effects of in vivo administration of KL or FL as single agents to normal subjects. The effects of KL are based on studies in mouse, rat, dogs, nonhuman primates, and humans, whereas the effects of FL are predominantly based on studies in mouse and nonhuman primates.
Abbreviations: +, increase; NE, no effect; +/NE, effect found in some but not all species investigated; ND, not determined.