In Vitro Effects of KL and FL in the Murine and Human Hematopoietic System
| Cell Type . | Response . | KL . | FL . |
|---|---|---|---|
| Primitive progenitors/candidate stem cells | Growth | Synergy | Synergy |
| Viability | + | + | |
| Adhesion | + | ND | |
| Erythroid progenitors | |||
| BFU-E | Growth | Synergy | − |
| Adhesion | + | − | |
| CFU-E | Growth | + | − |
| Myeloid (GM) progenitors | Growth | Synergy | Synergy |
| Viability | + | + | |
| Adhesion | + | ND | |
| Megakaryocytopoiesis | |||
| BFU-Mk/CFU-Mk | Growth | + | + |
| Mk maturation | + | − | |
| Mast cells | Growth | + | − |
| Maturation | + | − | |
| Adhesion | + | − | |
| Migration | + | − | |
| Activation | + | − | |
| B lymphopoiesis | |||
| Murine stem cells | Growth/ commitment | Weak | Strong |
| Murine pro-B cells | Growth | Synergy | Synergy |
| Human pro-B cells | Growth | − | Synergy |
| T lymphopoiesis | |||
| Murine pro-T cells | Growth | Synergy | Synergy |
| Human pro-T cells | Stromadependent growth | Synergy | Synergy |
| NK cells | |||
| NK cell progenitors | Growth | Synergy | Synergy |
| NK cells | Growth | Synergy | ND |
| Viability | + | ND | |
| Dendritic cells | |||
| DC progenitors | Growth | Synergy | Synergy |
| Cell Type . | Response . | KL . | FL . |
|---|---|---|---|
| Primitive progenitors/candidate stem cells | Growth | Synergy | Synergy |
| Viability | + | + | |
| Adhesion | + | ND | |
| Erythroid progenitors | |||
| BFU-E | Growth | Synergy | − |
| Adhesion | + | − | |
| CFU-E | Growth | + | − |
| Myeloid (GM) progenitors | Growth | Synergy | Synergy |
| Viability | + | + | |
| Adhesion | + | ND | |
| Megakaryocytopoiesis | |||
| BFU-Mk/CFU-Mk | Growth | + | + |
| Mk maturation | + | − | |
| Mast cells | Growth | + | − |
| Maturation | + | − | |
| Adhesion | + | − | |
| Migration | + | − | |
| Activation | + | − | |
| B lymphopoiesis | |||
| Murine stem cells | Growth/ commitment | Weak | Strong |
| Murine pro-B cells | Growth | Synergy | Synergy |
| Human pro-B cells | Growth | − | Synergy |
| T lymphopoiesis | |||
| Murine pro-T cells | Growth | Synergy | Synergy |
| Human pro-T cells | Stromadependent growth | Synergy | Synergy |
| NK cells | |||
| NK cell progenitors | Growth | Synergy | Synergy |
| NK cells | Growth | Synergy | ND |
| Viability | + | ND | |
| Dendritic cells | |||
| DC progenitors | Growth | Synergy | Synergy |
Cell types or responses in which neither KL nor FL are known to have an effect are not listed.
Abbreviations: −, no effect found on indicated response (in some cases not specifically investigated but cell type lacks receptor for indicated ligand); +, stimulatory effect of ligand alone on indicated response; synergy, effect predominantly through synergistic interaction with other cytokines; ND, not determined.