Renal and Hepatic Responses
. | # . | Proteinuria (<150 mg/d) . | Alkaline Phosphatase (<120 U/L) . | Albumin (3.5-5.5 g/dL) . | Creatinine (<1.5 mg/dL) . | ||||
---|---|---|---|---|---|---|---|---|---|
Pre . | Post . | Pre . | Post . | Pre . | Post . | Pre . | Post . | ||
A | 6 | 11,370 | 1,573 | 124 | 108 | 2.3 | 4.0 | 1.0 | 0.9 |
7 | 12,800 | 11,400 | 104 | 77 | 2.2 | 2.5 | 1.0 | 4.1 | |
11 | 9,234 | 8,293 | 90 | 64 | 2.2 | 2.3 | 0.7 | 0.9 | |
13 | 9,653 | 7,320 | 135 | 111 | 2.1 | 3.1 | 0.8 | 0.9 | |
22 | 6,030 | 421 | 146 | 194 | 1.7 | 2.7 | 0.9 | 1.2 | |
23 | 16,390 | 21,625 | 59 | 61 | 1.2 | 1.7 | 0.9 | 7.1 | |
24 | 16,400 | 7,560 | 96 | 80 | 1.9 | 3.7 | 1.1 | 1.3 | |
B | 5 | 645 | 102 | 184 | 113 | 5.1 | 4.9 | 1.3 | 1.4 |
8 | 16,300 | 4,218 | 490 | 520 | 3.4 | 4.8 | 1.6 | 1.3 | |
10 | 2,880 | 1,135 | 1,280 | 551 | 3.3 | 3.9 | 0.8 | 0.9 | |
12 | 3,548 | 1,595 | 413 | 199 | 3.3 | 5.7 | 0.8 | 0.7 | |
17 | 23,595 | 2,728 | 2,820 | 586 | 1.3 | 3.9 | 0.5 | 0.7 | |
C | 14 | 3,542 | 992 | 362 | 278 | 4.0 | 5.1 | 1.5 | 1.7 |
18 | 2,420 | 4,189 | 1,488 | 160 | 2.7 | 3.3 | 0.9 | 1.3 |
. | # . | Proteinuria (<150 mg/d) . | Alkaline Phosphatase (<120 U/L) . | Albumin (3.5-5.5 g/dL) . | Creatinine (<1.5 mg/dL) . | ||||
---|---|---|---|---|---|---|---|---|---|
Pre . | Post . | Pre . | Post . | Pre . | Post . | Pre . | Post . | ||
A | 6 | 11,370 | 1,573 | 124 | 108 | 2.3 | 4.0 | 1.0 | 0.9 |
7 | 12,800 | 11,400 | 104 | 77 | 2.2 | 2.5 | 1.0 | 4.1 | |
11 | 9,234 | 8,293 | 90 | 64 | 2.2 | 2.3 | 0.7 | 0.9 | |
13 | 9,653 | 7,320 | 135 | 111 | 2.1 | 3.1 | 0.8 | 0.9 | |
22 | 6,030 | 421 | 146 | 194 | 1.7 | 2.7 | 0.9 | 1.2 | |
23 | 16,390 | 21,625 | 59 | 61 | 1.2 | 1.7 | 0.9 | 7.1 | |
24 | 16,400 | 7,560 | 96 | 80 | 1.9 | 3.7 | 1.1 | 1.3 | |
B | 5 | 645 | 102 | 184 | 113 | 5.1 | 4.9 | 1.3 | 1.4 |
8 | 16,300 | 4,218 | 490 | 520 | 3.4 | 4.8 | 1.6 | 1.3 | |
10 | 2,880 | 1,135 | 1,280 | 551 | 3.3 | 3.9 | 0.8 | 0.9 | |
12 | 3,548 | 1,595 | 413 | 199 | 3.3 | 5.7 | 0.8 | 0.7 | |
17 | 23,595 | 2,728 | 2,820 | 586 | 1.3 | 3.9 | 0.5 | 0.7 | |
C | 14 | 3,542 | 992 | 362 | 278 | 4.0 | 5.1 | 1.5 | 1.7 |
18 | 2,420 | 4,189 | 1,488 | 160 | 2.7 | 3.3 | 0.9 | 1.3 |
All of these patients had amyloid-related renal involvement, and patients in groups B and C had both renal and hepatic involvement. The patients in group A had predominant renal involvement, those in B predominant hepatic, and in C predominant cardiac involvement. The columns give pre- and post-therapy values for laboratory tests obtained for each patient, the post-therapy value being from the most recent follow-up. (Normal values)