Table 1.

Patient Characteristics at Enrollment (n = 25)

Median age  48 (range, 29-60)  
Men  13 
Women  12  
SWOG performance status  
 1  10  
 2 12  
 3  3  
Months from diagnosis  
 0-3  
 3-12  18  
 >12  3  
Prior oral melphalan  
 0 16  
 <200 mg  2  
 >200 mg  7  
Median number of biopsies positive for amyloid   2 (range, 2-4) 
M-protein in serum and urine  14  
M-protein in urine only 9  
M-protein light chain isotype: K/λ  5/18 
Clonal bone marrow plasmacytosis only  2  
Marrow amyloid depositions present  18  
Grade 2 or 3 marrow amyloid depositions 8  
Hypogammaglobulinemia  17  
Howell-Jolly bodies 
Median age  48 (range, 29-60)  
Men  13 
Women  12  
SWOG performance status  
 1  10  
 2 12  
 3  3  
Months from diagnosis  
 0-3  
 3-12  18  
 >12  3  
Prior oral melphalan  
 0 16  
 <200 mg  2  
 >200 mg  7  
Median number of biopsies positive for amyloid   2 (range, 2-4) 
M-protein in serum and urine  14  
M-protein in urine only 9  
M-protein light chain isotype: K/λ  5/18 
Clonal bone marrow plasmacytosis only  2  
Marrow amyloid depositions present  18  
Grade 2 or 3 marrow amyloid depositions 8  
Hypogammaglobulinemia  17  
Howell-Jolly bodies