Prevalence of Mutant Genotypes in 72 Individuals With Ischemic Stroke Before 50 Years of Age and in 198 Controls
| Carriers . | Patients (n = 72) . | Controls (n = 198) . | P Value . |
|---|---|---|---|
| Factor V G/A | 4 (5.5%) | 5 (2.5%) | .2199 |
| Factor V A/A | 0 | 1 (0.5%) | .5457 |
| Factor II G/A | 6 (8.3%) | 5 (2.5%) | .0328 |
| Factor II A/A | 2 (2.8%) | 0 | .0186 |
| FV G/A + FII G/A | 1 (1.4%) | 0 | .0966 |
| MTHFR C/T | 27 (37.5%) | 98 (49.5%) | .0805 |
| MTHFR T/T | 17 (23.6%) | 35 (17.7%) | .2742 |
| Allele Frequency | Patients | Controls | P Value |
| Factor V A allele (95% CI) | 3.4% (0.4-6.4) | 1.7% (0.4-3.0) | .2347 |
| Factor II A allele (95% CI) | 7.6% (3.3-11.9) | 1.2% (0.1-2.3) | .0001 |
| MTHFR T allele (95% CI) | 42.3% (34.2-50.4) | 42.4% (37.5-47.2) | .9895 |
| Carriers . | Patients (n = 72) . | Controls (n = 198) . | P Value . |
|---|---|---|---|
| Factor V G/A | 4 (5.5%) | 5 (2.5%) | .2199 |
| Factor V A/A | 0 | 1 (0.5%) | .5457 |
| Factor II G/A | 6 (8.3%) | 5 (2.5%) | .0328 |
| Factor II A/A | 2 (2.8%) | 0 | .0186 |
| FV G/A + FII G/A | 1 (1.4%) | 0 | .0966 |
| MTHFR C/T | 27 (37.5%) | 98 (49.5%) | .0805 |
| MTHFR T/T | 17 (23.6%) | 35 (17.7%) | .2742 |
| Allele Frequency | Patients | Controls | P Value |
| Factor V A allele (95% CI) | 3.4% (0.4-6.4) | 1.7% (0.4-3.0) | .2347 |
| Factor II A allele (95% CI) | 7.6% (3.3-11.9) | 1.2% (0.1-2.3) | .0001 |
| MTHFR T allele (95% CI) | 42.3% (34.2-50.4) | 42.4% (37.5-47.2) | .9895 |
Odds ratio for ischemic stroke: Carriership of factor II A allele (both G/A and A/A genotypes): 5.5 (95% CI, 1.7-17.0). After adjustment for other inherited causes of thrombophilia: carriership of factor II A allele: 5.1 (95% CI, 1.6-16.3); heterozygous genotype: 3.8 (95% CI, 1.1-13.1); homozygous genotype: 208.0 (95% CI, 14.4-2,957.2).