Table 3. Percentage of Lymphocytes and... | American Society of Hematology

Table 3.

Percentage of Lymphocytes and Monocytes Expressing Membrane-Bound TNF-α and Membrane-Bound TNFRs (p55 and p75) in Three Different Clinical Groups of HIV-1–Infected Patients and Healthy Controls

	Lymphocytes			Monocytes
	TNF-α	p55-TNFR	p75-TNFR	TNF-α	p55-TNFR	p75-TNFR
Controls (n = 12)	2.1	3.4	10.8	2.4	3.9	9.1
	(1.1-4.5)	(0-10.1)	(8.4-12.1)	(0.4-9.8)	(0.3-13.6)	(0.3-14.5)
CDC Group A (n = 12)	7.7^3-150	5.5^3-151	17.0^*†	17.7‡ρ	11.9^*†	15.1ρ
	(2.9-12.2)	(1.4-13.9)	(5.7-23.1)	(9.0-37.2)	(4.4-50.4)	(7.0-28.3)
CDC Group B (n = 11)	8.0^3-152	7.3^3-151	19.2*ρ	7.2	28.2^†‡	20.3*ρ
	(4.3-16.8)	(3.3-10.2)	(10.1-33.2)	(3.3-11.3)	(25.1-55.7)	(5.1-35.7)
CDC Group C (n = 10)	5.4	0.8	5.8^3-150	5.8	4.9	2.7^3-152
	(1.0-8.3)	(0-3.2)	(2.6-8.8)	(2.5-11.9)	(0-10.5)	(0.1-5.9)

	Lymphocytes			Monocytes
	TNF-α	p55-TNFR	p75-TNFR	TNF-α	p55-TNFR	p75-TNFR
Controls (n = 12)	2.1	3.4	10.8	2.4	3.9	9.1
	(1.1-4.5)	(0-10.1)	(8.4-12.1)	(0.4-9.8)	(0.3-13.6)	(0.3-14.5)
CDC Group A (n = 12)	7.7^3-150	5.5^3-151	17.0^*†	17.7‡ρ	11.9^*†	15.1ρ
	(2.9-12.2)	(1.4-13.9)	(5.7-23.1)	(9.0-37.2)	(4.4-50.4)	(7.0-28.3)
CDC Group B (n = 11)	8.0^3-152	7.3^3-151	19.2*ρ	7.2	28.2^†‡	20.3*ρ
	(4.3-16.8)	(3.3-10.2)	(10.1-33.2)	(3.3-11.3)	(25.1-55.7)	(5.1-35.7)
CDC Group C (n = 10)	5.4	0.8	5.8^3-150	5.8	4.9	2.7^3-152
	(1.0-8.3)	(0-3.2)	(2.6-8.8)	(2.5-11.9)	(0-10.5)	(0.1-5.9)

The membrane-bound components of the TNF system were analyzed by flow cytometry in asymptomatic HIV-1–infected patients (CDC group A), symptomatic non-AIDS HIV-1–infected patients (CDC group B), AIDS patients (CDC group C), and healthy blood donors. Data are given as medians and 25th to 75th percentiles.

F3-150

P < .05 versus controls.

F3-151

P < .05 versus CDC group C.

F3-152

P < .01 versus controls.

ρ P < .01 versus CDC group C.

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