Percentage of PBMC Expressing Membrane-Bound TNF-α and Membrane-Bound TNFRs (p55 and p75) in Three Different Clinical Groups of HIV-1–Infected Patients and Healthy Controls
| . | TNF-α . | p55-TNFR . | p75-TNFR . |
|---|---|---|---|
| Controls | |||
| (n = 12) | 1.5 | 4.2 | 7.1 |
| (0.3-4.0) | (1.2-10.0) | (3.3-12.8) | |
| CDC Group A (n = 12) | 9.1*† | 7.1†‡ | 14.5†‡ |
| (6.3-12.4) | (3.4-12.1) | (7.7-21.1) | |
| CDC Group B (n = 11) | 8.5*† | 10.9*ρ | 25.7*ρ |
| (5.1-12.3) | (9.6-15.3) | (13.4-26.9) | |
| CDC Group C (n = 10) | 4.6 | 2.8 | 2.4‡ |
| (0.2-7.5) | (0.3-4.7) | (0.2-4.1) |
| . | TNF-α . | p55-TNFR . | p75-TNFR . |
|---|---|---|---|
| Controls | |||
| (n = 12) | 1.5 | 4.2 | 7.1 |
| (0.3-4.0) | (1.2-10.0) | (3.3-12.8) | |
| CDC Group A (n = 12) | 9.1*† | 7.1†‡ | 14.5†‡ |
| (6.3-12.4) | (3.4-12.1) | (7.7-21.1) | |
| CDC Group B (n = 11) | 8.5*† | 10.9*ρ | 25.7*ρ |
| (5.1-12.3) | (9.6-15.3) | (13.4-26.9) | |
| CDC Group C (n = 10) | 4.6 | 2.8 | 2.4‡ |
| (0.2-7.5) | (0.3-4.7) | (0.2-4.1) |
The membrane-bound components of the TNF system were analyzed by flow cytometry in asymptomatic HIV-1–infected patients (CDC group A), symptomatic non-AIDS HIV-1–infected patients (CDC group B), AIDS patients (CDC group C), and healthy blood donors. Data are given as medians and 25th to 75th percentiles.
P < .01 versus control.
P < .03 versus CDC group C.
P < .05 versus controls.
ρ P < .001 versus CDC group C.