Blood Parameters for Donors and Their Respective Recipients at Four-Week Intervals Posttransplantation
| . | Donor . | Baselines . | 4 wk . | 8 wk . | 12 wk . | 16 wk . | 20 wk . | 24 wk . |
|---|---|---|---|---|---|---|---|---|
| ZPP | ||||||||
| +/+ | 50 | 27.5 ± 2.3 | 59 ± 7.1 | 39.3 ± 3.3 | 36 ± 2.8 | 34.7 ± 5.7 | 25.4 ± 5.4 | 43.8 ± 5.3 |
| hbd/hbd | 325 | 24.7 ± 2.7 | 181.7 ± 8.7 | 249.3 ± 36.5 | 243.3 ± 27.9 | 272.5 ± 27.9 | 251.3 ± 13.2 | 300.5 ± 34.5 |
| MCV | ||||||||
| +/+ | 47.1 | 50.4 ± 0.4 | 47.3 ± 1.0 | 48.7 ± 1.7 | 50.3 ± 2.5 | 43.4 ± 1.3 | 47.5 ± 2.0 | 48.8 ± 3.0 |
| hbd/hbd | 29.4 | 51.4 ± 1.0 | 39.0 ± 0.6 | 34.7 ± 1.4 | 34.5 ± 0.9 | 33.9 ± 1.5 | 34.5 ± 1.5 | 32.5 ± 1.6 |
| MCHC | ||||||||
| +/+ | 28.2 | 29.4 ± 1.3 | 33.6 ± 0.6 | 32.6 ± 1.6 | 31.0 ± 1.2 | 36.2 ± 1.6 | 31.4 ± 0.8 | 33.4 ± 2.2 |
| hbd/hbd | 27.4 | 31.4 ± 0.7 | 28.5 ± 0.3 | 27.6 ± 0.9 | 28.7 ± 1.6 | 29.2 ± 1.5 | 25.8 ± 1.2 | 28.8 ± 1.4 |
| . | Donor . | Baselines . | 4 wk . | 8 wk . | 12 wk . | 16 wk . | 20 wk . | 24 wk . |
|---|---|---|---|---|---|---|---|---|
| ZPP | ||||||||
| +/+ | 50 | 27.5 ± 2.3 | 59 ± 7.1 | 39.3 ± 3.3 | 36 ± 2.8 | 34.7 ± 5.7 | 25.4 ± 5.4 | 43.8 ± 5.3 |
| hbd/hbd | 325 | 24.7 ± 2.7 | 181.7 ± 8.7 | 249.3 ± 36.5 | 243.3 ± 27.9 | 272.5 ± 27.9 | 251.3 ± 13.2 | 300.5 ± 34.5 |
| MCV | ||||||||
| +/+ | 47.1 | 50.4 ± 0.4 | 47.3 ± 1.0 | 48.7 ± 1.7 | 50.3 ± 2.5 | 43.4 ± 1.3 | 47.5 ± 2.0 | 48.8 ± 3.0 |
| hbd/hbd | 29.4 | 51.4 ± 1.0 | 39.0 ± 0.6 | 34.7 ± 1.4 | 34.5 ± 0.9 | 33.9 ± 1.5 | 34.5 ± 1.5 | 32.5 ± 1.6 |
| MCHC | ||||||||
| +/+ | 28.2 | 29.4 ± 1.3 | 33.6 ± 0.6 | 32.6 ± 1.6 | 31.0 ± 1.2 | 36.2 ± 1.6 | 31.4 ± 0.8 | 33.4 ± 2.2 |
| hbd/hbd | 27.4 | 31.4 ± 0.7 | 28.5 ± 0.3 | 27.6 ± 0.9 | 28.7 ± 1.6 | 29.2 ± 1.5 | 25.8 ± 1.2 | 28.8 ± 1.4 |
Blood parameters for normal and mutant donors are presented in column 1. The congenic recipients of either C57BL6/J-+hbd/+hbd or -hbd/hbd marrow were assayed at 4-week intervals (columns 2-8). Abbreviations and units are the same as in Table 1. For recipients of -hbd/hbd marrow at all time points, n = 6. For recipients of -+hbd/+hbd marrow up to 16 weeks, n = 6. For recipients of +hbd/+hbd marrow at 20 and 24 weeks, n = 5. Values are represented as the mean ± SE. For the ZPP and MCV parameters, P < .01. For MCHC, P ≤ .01 at 4, 16, and 20 weeks, P < .05 at 8 weeks, P = .25 at 12 weeks, and P = .1 at 24 weeks. The P values are based on the t-test for equal variance (two-tailed).