Transfusion Requirements and Blood Cell Regeneration After 5 Gy TBI and Growth Factor Treatment
| Treatment . | No. of Monkeys . | No. of Transfusions . | Thrombocytes . | Reticulocytes . | Neutrophils . |
|---|---|---|---|---|---|
| . | . | . | >40 × 109/L (d) . | >1% (d) . | >0.5 × 109/L (d) . |
| TPO | 4 | 0/0/1/1* | NA | 14.2 ± 3.6* | 21.5 ± 2.4 |
| TPO + GM-CSF | 4 | 0/0/0/0* | NA | 10.5 ± 1.7* | 14.5 ± 2.6* |
| TPO + G-CSF | 4 | 0/0/1/0* | NA | 13.2 ± 2.6* | 14.2 ± 1.2* |
| GM-CSF | 4 | 3/2/2/2 | 13.2 ± 1.7 | 16.2 ± 2.5* | 17.7 ± 2.2* |
| G-CSF | 3 | 1/2/1 | 13.3 ± 1.5 | 17.3 ± 0.6 | 19.7 ± 3.2 |
| Placebo | 4 | 3/6/3/3 | 19.5 ± 7.0 | 20.5 ± 2.1 | 22.5 ± 2.4 |
| Treatment . | No. of Monkeys . | No. of Transfusions . | Thrombocytes . | Reticulocytes . | Neutrophils . |
|---|---|---|---|---|---|
| . | . | . | >40 × 109/L (d) . | >1% (d) . | >0.5 × 109/L (d) . |
| TPO | 4 | 0/0/1/1* | NA | 14.2 ± 3.6* | 21.5 ± 2.4 |
| TPO + GM-CSF | 4 | 0/0/0/0* | NA | 10.5 ± 1.7* | 14.5 ± 2.6* |
| TPO + G-CSF | 4 | 0/0/1/0* | NA | 13.2 ± 2.6* | 14.2 ± 1.2* |
| GM-CSF | 4 | 3/2/2/2 | 13.2 ± 1.7 | 16.2 ± 2.5* | 17.7 ± 2.2* |
| G-CSF | 3 | 1/2/1 | 13.3 ± 1.5 | 17.3 ± 0.6 | 19.7 ± 3.2 |
| Placebo | 4 | 3/6/3/3 | 19.5 ± 7.0 | 20.5 ± 2.1 | 22.5 ± 2.4 |
Data for individual monkeys or the mean ± SD are shown.
Abbreviation: NA, not applicable, ie, level <40 × 109/L not reached in the majority of monkeys.
Statistically significantly different from placebo-treated monkeys (P < .05).