Clinical Characteristics of the Patients With Myelofibrosis With Myeloid Metaplasia in the Study Cohort
| . | All Patients . | Patients Who Underwent Splenectomy . | Patients Who Did Not Undergo Splenectomy . | P . |
|---|---|---|---|---|
| (N = 549) | (N = 87) | (N = 462) | ||
| Patient age at diagnosis (yr), range (median) | 22-92 (63) | 29-72 (55) | 22-92 (64) | <.001 |
| M/F (no.) | 325/224 | 56/31 | 269/193 | NS |
| Hematologic data at diagnosis, range (median) | ||||
| Hemoglobin (g/dL) | 3.4-20.2 (10.6) | 4.6-14.8 (10.5) | 3.4-20.2 (10.6) | NS |
| White blood cell count (×109/L)-150 | 0.5-145 (9.1) | 2.0-73.0 (6.7) | 0.5-145 (9.8) | .01 |
| Platelet count (×109/L) | 14-1,768 (280) | 30-1,500 (214) | 14-1,768 (291) | .02 |
| (N = 371) | (N = 59) | (N = 312) | ||
| Immature myeloid cells in peripheral blood, range (median)-151 | 0-58 (4) | 0-42 (3) | 0-58 (4) | NS |
| Patients with detectable blasts cell in peripheral blood at diagnosis, no. (percentage of total) | 102 (27.4) | 16 (27.1) | 86 (27.6) | NS |
| Blast cells at diagnosis in patients with detectable blasts, range (median)-151 | 1-9 (2) | 1-8 (2) | 1-9 (3) | NS |
| Erythroblasts in peripheral blood, 109/L, range (median) | 0-38 (2) | 0-13 (1) | 0-38 (2) | NS |
| (N = 513) | (N = 84) | (N = 429) | ||
| Spleen size at diagnosis, no. of patients (percentage of total) | ||||
| Grade 0 | 44 (8.6) | 3 (3.5) | 41 (9.5) | NS |
| Grade I | 328 (63.9) | 49 (58.3) | 279 (65.0) | NS |
| Grade II | 121 (23.6) | 22 (26.2) | 99 (23.1) | NS |
| Grade III | 20 (3.9) | 10 (11.9) | 10 (2.3) | .02 |
| (N = 498) | (N = 67) | (N = 431) | ||
| Anemia progression index-152 (g/dL hemoglobin/mo), range (median) | 0.92 to −4.65 (−0.02) | 0.70 to −1.05 (−0.05) | 0.92 to −4.65 (−0.02) | NS |
| Thrombocytopenia progression index-152(109/L platelets/mo), range (median) | 38.8 to −286 (−3.5) | 38.1 to −38 (−2.86) | 38.8 to −286 (−3.73) | .002 |
| Splenomegaly progression index-152 (grade/mo), range (median) | −0.33 to 0.27 (0.01) | −0.25 to 0.25 (0.02) | −0.33 to 0.27 (0.01) | NS |
| . | All Patients . | Patients Who Underwent Splenectomy . | Patients Who Did Not Undergo Splenectomy . | P . |
|---|---|---|---|---|
| (N = 549) | (N = 87) | (N = 462) | ||
| Patient age at diagnosis (yr), range (median) | 22-92 (63) | 29-72 (55) | 22-92 (64) | <.001 |
| M/F (no.) | 325/224 | 56/31 | 269/193 | NS |
| Hematologic data at diagnosis, range (median) | ||||
| Hemoglobin (g/dL) | 3.4-20.2 (10.6) | 4.6-14.8 (10.5) | 3.4-20.2 (10.6) | NS |
| White blood cell count (×109/L)-150 | 0.5-145 (9.1) | 2.0-73.0 (6.7) | 0.5-145 (9.8) | .01 |
| Platelet count (×109/L) | 14-1,768 (280) | 30-1,500 (214) | 14-1,768 (291) | .02 |
| (N = 371) | (N = 59) | (N = 312) | ||
| Immature myeloid cells in peripheral blood, range (median)-151 | 0-58 (4) | 0-42 (3) | 0-58 (4) | NS |
| Patients with detectable blasts cell in peripheral blood at diagnosis, no. (percentage of total) | 102 (27.4) | 16 (27.1) | 86 (27.6) | NS |
| Blast cells at diagnosis in patients with detectable blasts, range (median)-151 | 1-9 (2) | 1-8 (2) | 1-9 (3) | NS |
| Erythroblasts in peripheral blood, 109/L, range (median) | 0-38 (2) | 0-13 (1) | 0-38 (2) | NS |
| (N = 513) | (N = 84) | (N = 429) | ||
| Spleen size at diagnosis, no. of patients (percentage of total) | ||||
| Grade 0 | 44 (8.6) | 3 (3.5) | 41 (9.5) | NS |
| Grade I | 328 (63.9) | 49 (58.3) | 279 (65.0) | NS |
| Grade II | 121 (23.6) | 22 (26.2) | 99 (23.1) | NS |
| Grade III | 20 (3.9) | 10 (11.9) | 10 (2.3) | .02 |
| (N = 498) | (N = 67) | (N = 431) | ||
| Anemia progression index-152 (g/dL hemoglobin/mo), range (median) | 0.92 to −4.65 (−0.02) | 0.70 to −1.05 (−0.05) | 0.92 to −4.65 (−0.02) | NS |
| Thrombocytopenia progression index-152(109/L platelets/mo), range (median) | 38.8 to −286 (−3.5) | 38.1 to −38 (−2.86) | 38.8 to −286 (−3.73) | .002 |
| Splenomegaly progression index-152 (grade/mo), range (median) | −0.33 to 0.27 (0.01) | −0.25 to 0.25 (0.02) | −0.33 to 0.27 (0.01) | NS |
Abbreviation: NS, not significant.
White blood cell counts were corrected for the presence of circulating erythroblasts.
Percentage of white blood cells.
Progression indices represent the rate of change of the parameter during the course of the disease before splenectomy. A positive value indicates an increase and a negative value indicates a decrease in the value of the parameter.