Pattern of Disease Spread in SCID Mice and NOD/SCID Mice Engrafted With T-Cell Lineage Leukemia Cells
| Patient No. . | Mouse No. . | Mouse Survival (d) . | Percent Human Cells in Hematopoietic Organs . | |||
|---|---|---|---|---|---|---|
| . | . | . | (determined by flow cytometry) . | |||
| . | . | . | BM . | PB . | SP . | THY . |
| SCID mice | ||||||
| T2 | 1 | 109 | 88 | — | 58 | 94 |
| T4 | 1 | 103 | 45 | — | — | 43 |
| T5 | 1 | 28 | 35 | 58 | 31 | — |
| T6 | 1 | 74 | 68 | — | — | — |
| 2 | 47 | 96 | — | 78 | — | |
| 3 | 50 | 90 | — | — | — | |
| 4 | 50 | 93 | — | — | — | |
| T7 | 1 | 143 | — | 63 | 24 | 70 |
| T8 | 1 | 97 | — | — | 86 | — |
| 2 | 97 | — | — | 83 | — | |
| T9 | 1 | 44 | 84 | 88 | 74 | — |
| 2 | 58 | — | 87 | — | — | |
| 3 | 44 | 91 | 48 | — | — | |
| T10 | 1 | 123 | — | 7 | 28 | — |
| T12 | 1 | 190 | 91 | 19 | 11 | 99 |
| 2 | 148 | — | 73 | 53 | 62 | |
| T14 | 1 | 164 | 26 | 9 | 34 | 30 |
| T16 | 1 | 96 | — | 93 | — | — |
| 2 | 128 | — | 96 | 16 | — | |
| T18 | 1 | 69 | 45 | — | 55 | — |
| 2 | 68 | — | — | 31 | — SCID mice injected with passaged human leukemia from SCID spleens | |
| T5 | 1 | 37 | — | — | 66.5 | — |
| T6 | 1 | 35 | — | — | 89.2 | — |
| T9 | 1 | 50 | — | — | 36 | — |
| 2 | 75 | — | 95 | 77 | — | |
| T18 | 1 | 53 | — | 94 | 83 | 53 NOD/SCID mice |
| T1 | 1 | 134 | — | 87 | 89 | — |
| 2 | 170 | — | 86 | 45 | — | |
| T3 | 1 | 182 | 83 | 86 | — | — |
| T11 | 1 | 214 | 69 | 27 | 72 | 0 |
| T13 | 1 | 120 | 37 | — | — | — |
| 2 | 207 | 23 | — | — | 0 | |
| T15 | 1 | 75 | 82 | 28 | 80 | 0 |
| 2 | 209 | 41 | — | — | 0 | |
| T17 | 1 | 209 | 97 | 51 | 95 | 0 |
| T19 | 1 | 62 | — | 48 | 39 | — |
| 2 | 207 | 29 | — | 65 | — | |
| Patient No. . | Mouse No. . | Mouse Survival (d) . | Percent Human Cells in Hematopoietic Organs . | |||
|---|---|---|---|---|---|---|
| . | . | . | (determined by flow cytometry) . | |||
| . | . | . | BM . | PB . | SP . | THY . |
| SCID mice | ||||||
| T2 | 1 | 109 | 88 | — | 58 | 94 |
| T4 | 1 | 103 | 45 | — | — | 43 |
| T5 | 1 | 28 | 35 | 58 | 31 | — |
| T6 | 1 | 74 | 68 | — | — | — |
| 2 | 47 | 96 | — | 78 | — | |
| 3 | 50 | 90 | — | — | — | |
| 4 | 50 | 93 | — | — | — | |
| T7 | 1 | 143 | — | 63 | 24 | 70 |
| T8 | 1 | 97 | — | — | 86 | — |
| 2 | 97 | — | — | 83 | — | |
| T9 | 1 | 44 | 84 | 88 | 74 | — |
| 2 | 58 | — | 87 | — | — | |
| 3 | 44 | 91 | 48 | — | — | |
| T10 | 1 | 123 | — | 7 | 28 | — |
| T12 | 1 | 190 | 91 | 19 | 11 | 99 |
| 2 | 148 | — | 73 | 53 | 62 | |
| T14 | 1 | 164 | 26 | 9 | 34 | 30 |
| T16 | 1 | 96 | — | 93 | — | — |
| 2 | 128 | — | 96 | 16 | — | |
| T18 | 1 | 69 | 45 | — | 55 | — |
| 2 | 68 | — | — | 31 | — SCID mice injected with passaged human leukemia from SCID spleens | |
| T5 | 1 | 37 | — | — | 66.5 | — |
| T6 | 1 | 35 | — | — | 89.2 | — |
| T9 | 1 | 50 | — | — | 36 | — |
| 2 | 75 | — | 95 | 77 | — | |
| T18 | 1 | 53 | — | 94 | 83 | 53 NOD/SCID mice |
| T1 | 1 | 134 | — | 87 | 89 | — |
| 2 | 170 | — | 86 | 45 | — | |
| T3 | 1 | 182 | 83 | 86 | — | — |
| T11 | 1 | 214 | 69 | 27 | 72 | 0 |
| T13 | 1 | 120 | 37 | — | — | — |
| 2 | 207 | 23 | — | — | 0 | |
| T15 | 1 | 75 | 82 | 28 | 80 | 0 |
| 2 | 209 | 41 | — | — | 0 | |
| T17 | 1 | 209 | 97 | 51 | 95 | 0 |
| T19 | 1 | 62 | — | 48 | 39 | — |
| 2 | 207 | 29 | — | 65 | — | |
Abbreviations: SP, spleen; −, data not available; 0, organ not detectable; THY, thymus.