Clinical, Hematologic, and Cytogenetic Data of Cases With Deletions or Translocations Involving 13q
| Patients . | S/A . | Diagnosis . | Karyotype . | Follow-up† . |
|---|---|---|---|---|
| Deletions | ||||
| 1 | F/57 | AMM | 46,XX[3/5] | 47‡ |
| 46,XX,del(13)(q13q21)[2/5] | ||||
| 2 | F/66 | AMM | 46,XX[3/10] | 59 |
| 46,XX,del(13)(q13q21)[7/10] | ||||
| 3 | M/40 | AMM | 46,XY,[4/10] | 46 |
| 46,XY,del(13)(q13q21)[6/10] | ||||
| 4 | M/65 | AMM | 46,XY,t(3;18)(p14;p11),del(5)(q14q34),del(13)(q13q21)[10/10] | 24 |
| 5 | M/55 | AMM | 46,XY,del(13)(q13q21)[15/15] | 19 |
| 6* | M/53 | MDS | 46,XY[6/17] | 12‡ |
| 46,XY,del(13)(q12q21)[11/17] | ||||
| 7 | M/55 | MDS | 46,XY,del(13)(q13q21)[10/10] | Lost |
| 8 | M/63 | MDS | 46,XY,del(13)(q13q21)[8/8] | 22‡ |
| 9 | F/66 | MDS | 46,XX[5/10] | 6 |
| 46,XX,del(5)(q21q32)[1/10] | ||||
| 46,XX,del(5)(q21q32),del(13)(q13q21)[4/10] | ||||
| 10 | F/72 | AML-M6 | 47,XX,del(8)(q?),del(13)(q14q22),+mar[10/10] | 55‡ |
| 11 | F/67 | AML | 47,XX,del(5)(q13q33),+8,del(13)(q12q21)[15/15] | 1‡ |
| 12 | F/36 | AML-M4 | 46,XX[3/10] | Lost |
| 47,XX,+8[3/10] | ||||
| 47,XX,+8,del(13)(q13q22)[4/10] | ||||
| 13* | M/66 | ET | 47,XY, der(5)t(1;5)(p22;q21),+der(6)t(2;6)(q22;p12),del(13)(q14q22),der(17)t(11;17) (q13;p13)[7/7] | Lost |
| 14 | F/69 | ET | 46,XX,del(13)(q13q21)[10/10] | Lost |
| 15* | M/64 | PV | 47,XY,del(1)(p36),+del(1)(p36),del(11)(q22q24),del(13)(q13q21)[7/9] | 177 |
| 46,XY,-5,+9[2/9] | ||||
| 16* | F/67 | CML | 46,XX,t(9;22)(q34;q11)[2/10] | Lost |
| 46,XX,t(9;22)(q34;q11),del(13)(q13q21)[8/10] | ||||
| 17 | F/77 | Atypical CML | 46,XX,del(13)(q13q21)[10/10] | 6‡ |
| Translocations | ||||
| 18 | M/73 | MDS | 43,X,-Y,del(5)(q13q21),der(7)t(7;20)(p11;p11),t(12;13)(p13;q14),17,der(19)t(17;19)(q21;q13),-20[9/16]/ 44,idem,+der(13)t(12;13)(p13;q14)[5/16]/44,idem,+13[2/16] | 2‡ |
| 19 | M/87 | MDS | 45,X,-Y[1/13] | Lost |
| 45,X,-Y,del(5)(q12q34)[1/13] | ||||
| 45,X,-Y,t(2;12;13)(p14;q24;q13),del(5)(q12q34)[11/13] | ||||
| 20 | F/58 | AML-M6 | 52,XX,del(3)(p13p25),del(5)(q23q32),7,der(7)tas(7;13)(7pter→qter→13qter→q14),der(13)t(8;13)(q21;q13),+19, +mar1x2,+mar2,+mar3,+mar4[10/10] | 9‡ |
| Patients . | S/A . | Diagnosis . | Karyotype . | Follow-up† . |
|---|---|---|---|---|
| Deletions | ||||
| 1 | F/57 | AMM | 46,XX[3/5] | 47‡ |
| 46,XX,del(13)(q13q21)[2/5] | ||||
| 2 | F/66 | AMM | 46,XX[3/10] | 59 |
| 46,XX,del(13)(q13q21)[7/10] | ||||
| 3 | M/40 | AMM | 46,XY,[4/10] | 46 |
| 46,XY,del(13)(q13q21)[6/10] | ||||
| 4 | M/65 | AMM | 46,XY,t(3;18)(p14;p11),del(5)(q14q34),del(13)(q13q21)[10/10] | 24 |
| 5 | M/55 | AMM | 46,XY,del(13)(q13q21)[15/15] | 19 |
| 6* | M/53 | MDS | 46,XY[6/17] | 12‡ |
| 46,XY,del(13)(q12q21)[11/17] | ||||
| 7 | M/55 | MDS | 46,XY,del(13)(q13q21)[10/10] | Lost |
| 8 | M/63 | MDS | 46,XY,del(13)(q13q21)[8/8] | 22‡ |
| 9 | F/66 | MDS | 46,XX[5/10] | 6 |
| 46,XX,del(5)(q21q32)[1/10] | ||||
| 46,XX,del(5)(q21q32),del(13)(q13q21)[4/10] | ||||
| 10 | F/72 | AML-M6 | 47,XX,del(8)(q?),del(13)(q14q22),+mar[10/10] | 55‡ |
| 11 | F/67 | AML | 47,XX,del(5)(q13q33),+8,del(13)(q12q21)[15/15] | 1‡ |
| 12 | F/36 | AML-M4 | 46,XX[3/10] | Lost |
| 47,XX,+8[3/10] | ||||
| 47,XX,+8,del(13)(q13q22)[4/10] | ||||
| 13* | M/66 | ET | 47,XY, der(5)t(1;5)(p22;q21),+der(6)t(2;6)(q22;p12),del(13)(q14q22),der(17)t(11;17) (q13;p13)[7/7] | Lost |
| 14 | F/69 | ET | 46,XX,del(13)(q13q21)[10/10] | Lost |
| 15* | M/64 | PV | 47,XY,del(1)(p36),+del(1)(p36),del(11)(q22q24),del(13)(q13q21)[7/9] | 177 |
| 46,XY,-5,+9[2/9] | ||||
| 16* | F/67 | CML | 46,XX,t(9;22)(q34;q11)[2/10] | Lost |
| 46,XX,t(9;22)(q34;q11),del(13)(q13q21)[8/10] | ||||
| 17 | F/77 | Atypical CML | 46,XX,del(13)(q13q21)[10/10] | 6‡ |
| Translocations | ||||
| 18 | M/73 | MDS | 43,X,-Y,del(5)(q13q21),der(7)t(7;20)(p11;p11),t(12;13)(p13;q14),17,der(19)t(17;19)(q21;q13),-20[9/16]/ 44,idem,+der(13)t(12;13)(p13;q14)[5/16]/44,idem,+13[2/16] | 2‡ |
| 19 | M/87 | MDS | 45,X,-Y[1/13] | Lost |
| 45,X,-Y,del(5)(q12q34)[1/13] | ||||
| 45,X,-Y,t(2;12;13)(p14;q24;q13),del(5)(q12q34)[11/13] | ||||
| 20 | F/58 | AML-M6 | 52,XX,del(3)(p13p25),del(5)(q23q32),7,der(7)tas(7;13)(7pter→qter→13qter→q14),der(13)t(8;13)(q21;q13),+19, +mar1x2,+mar2,+mar3,+mar4[10/10] | 9‡ |
Abbreviations: S, sex; A, age; AMM, agnogenic myeloid metaplasia; ET, essential thrombocytemia; PV, polycytemia vera, AML, acute myeloid leukemia; MDS, myelodysplastic syndromes; CML, chronic myeloid leukemia.
Patients in which 13q anomaly was found during the course of disease.
Follow-up in months from the date of diagnosis.
Died.