Table 1. Influence of Stem Cell Factor... | American Society of Hematology

Table 1.

Influence of Stem Cell Factor on BFU-E Proliferation

SCF	No. of BFU-E Derived Colonies		No. of Cells × 10⁻⁴/BFU-E Derived Colony
	−	+	−	+
Normal
Day 7	40 ± 4	52 ± 5	0.11 ± 0.03	0.29 ± 0.05^*
10	57 ± 5	62 ± 6	0.54 ± 0.05	2.45 ± 0.18^*
14	79 ± 8	79 ± 7	1.96 ± 0.23	3.96 ± 0.50^*
Diamond-Blackfan
Day 10	6 ± 2	10 ± 2	0.22 ± 0.05	1.22 ± 0.23^*
14	8 ± 2	12 ± 4	0.51 ± 0.17	3.93 ± 0.94^*

SCF	No. of BFU-E Derived Colonies		No. of Cells × 10⁻⁴/BFU-E Derived Colony
	−	+	−	+
Normal
Day 7	40 ± 4	52 ± 5	0.11 ± 0.03	0.29 ± 0.05^*
10	57 ± 5	62 ± 6	0.54 ± 0.05	2.45 ± 0.18^*
14	79 ± 8	79 ± 7	1.96 ± 0.23	3.96 ± 0.50^*
Diamond-Blackfan
Day 10	6 ± 2	10 ± 2	0.22 ± 0.05	1.22 ± 0.23^*
14	8 ± 2	12 ± 4	0.51 ± 0.17	3.93 ± 0.94^*

Mean number of BFU-E ± SEM per 2 × 10⁵ PB MNC from 16 normal volunteer donors or 6 patients with DBA plated with 2 U/mL erythropoietin with or without 100 ng/mL human SCF. Mean number of cells × 10⁴ ± SEM per BFU-E derived colony counted on days 7 to 14 of culture are shown.

Indicates significant increase from control cultured without SCF (P < .05).

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