Table 1.

Survey of Fib420 Plasma Levels in Adults and Newborn Infants

AdultFetal
FibrinogenFib420MolarFibrinogenFib420Molar
(mg/mL)(μg/mL)%Fib420(mg/mL)(μg/mL)%Fib420
2.7 33 1.0 2.5 120 3.9 
2.7 26 0.8 1.9 81 3.4 
2.7 35 1.0 2.6 120 3.7 
2.8 30 0.9 2.6 99 3.1 
2.7 33 1.0 2.4 58 1.9 
3.7 23 0.5 2.5 121 3.9 
2.5 31 1.0 2.6 119 3.7 
2.3 37 1.3 2.6 101 3.2 
1.9 24 1.1 1.8 52 2.4 
2.4 35 1.2 2.8 100 2.8 
1.7 21 1.0 2.8 124 3.6 
3.1 47 1.2 2.1 70 2.6 
2.6 31 1.0 2.6 136 4.2 
2.9 40 1.1 2.1 80 3.1 
1.8 28 1.2 2.2 67 2.5 
2.7 29 0.9 2.0 53 2.2 
3.2 31 0.8 3.3 150 3.7 
2.2 37 1.3 2.6 126 3.9 
3.5 39 0.9 2.4 93 3.2 
2.0 33 1.3 2.2 102 3.8 
3.4 41 1.0 2.2 87 3.2 
2.4 49 1.7 3.2 133 3.4 
2.3 42 1.5 1.8 92 4.2 
2.7 24 0.7 3.4 129 3.1 
3.8 43 0.9 2.9 82 2.3 
Mean: 
2.7 34 1.1 2.5 100 3.2 
SD: 
0.6 7 0.3 0.4 28 0.6 
AdultFetal
FibrinogenFib420MolarFibrinogenFib420Molar
(mg/mL)(μg/mL)%Fib420(mg/mL)(μg/mL)%Fib420
2.7 33 1.0 2.5 120 3.9 
2.7 26 0.8 1.9 81 3.4 
2.7 35 1.0 2.6 120 3.7 
2.8 30 0.9 2.6 99 3.1 
2.7 33 1.0 2.4 58 1.9 
3.7 23 0.5 2.5 121 3.9 
2.5 31 1.0 2.6 119 3.7 
2.3 37 1.3 2.6 101 3.2 
1.9 24 1.1 1.8 52 2.4 
2.4 35 1.2 2.8 100 2.8 
1.7 21 1.0 2.8 124 3.6 
3.1 47 1.2 2.1 70 2.6 
2.6 31 1.0 2.6 136 4.2 
2.9 40 1.1 2.1 80 3.1 
1.8 28 1.2 2.2 67 2.5 
2.7 29 0.9 2.0 53 2.2 
3.2 31 0.8 3.3 150 3.7 
2.2 37 1.3 2.6 126 3.9 
3.5 39 0.9 2.4 93 3.2 
2.0 33 1.3 2.2 102 3.8 
3.4 41 1.0 2.2 87 3.2 
2.4 49 1.7 3.2 133 3.4 
2.3 42 1.5 1.8 92 4.2 
2.7 24 0.7 3.4 129 3.1 
3.8 43 0.9 2.9 82 2.3 
Mean: 
2.7 34 1.1 2.5 100 3.2 
SD: 
0.6 7 0.3 0.4 28 0.6 

Plasma samples were analyzed from an adult and a fetal cohort representing 25 normal blood donations and 25 placental/umbilical cord blood donations, respectively. Fibrinogen, expressed in mg per mL plasma and rounded to the nearest tenth, represents the mean of quadruplicate determinations by rocket immunoelectrophoresis. Molar %Fib420 equals the mean of quadruplicate molar ratio determinations by quantitative Western blot assay and is presented to the nearest tenth of a percent. Levels of Fib420, in μg/mL plasma and rounded to the nearest whole number, were calculated from these values for fibrinogen and molar %Fib420 as described in Materials and Methods.

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