Characteristics of Mice in Control Group Transplanted With Empty pSRαMSVtkneo-Infected Marrow (C1 Through C4) and Mice Receiving Marrow Infected With the Retroviral Construct pSRαMSVtkneo–NPM-ALK (GT1 Through GT4)
| Transduction With . | Survival Posttransplant (weeks) . | Sites of Tumor Involvement . |
|---|---|---|
| pSRαMSVtkneo | ||
| C1 | 46 | Mesenteric lymph nodes, kidneys, lungs, liver, and spleen (spontaneous tumor occurrence with advanced age and irradiation) |
| C2 | >60 | — |
| C3 | >60 | — |
| C4 | >60 | — |
| pSRαMSVtkneo–NPM-ALK | ||
| GT1 | 13 | Not analyzable (unwitnessed death) |
| GT2 | 14 | Mesenteric lymph nodes, metastases to kidneys and lungs |
| GT3 | 14 | None evident (killed because of severe weight loss) |
| GT4 | 15 | Mesenteric lymph nodes, metastases to kidneys, lungs, liver, and spleen |
| GT5 | 23 | Paraspinal area (killed because of hind limb paralysis and severe weight loss) |
| GT6 | 23 | Mesenteric lymph nodes, metastases to kidneys, lungs, and spleen |
| GT7 | >29 | — |
| Transduction With . | Survival Posttransplant (weeks) . | Sites of Tumor Involvement . |
|---|---|---|
| pSRαMSVtkneo | ||
| C1 | 46 | Mesenteric lymph nodes, kidneys, lungs, liver, and spleen (spontaneous tumor occurrence with advanced age and irradiation) |
| C2 | >60 | — |
| C3 | >60 | — |
| C4 | >60 | — |
| pSRαMSVtkneo–NPM-ALK | ||
| GT1 | 13 | Not analyzable (unwitnessed death) |
| GT2 | 14 | Mesenteric lymph nodes, metastases to kidneys and lungs |
| GT3 | 14 | None evident (killed because of severe weight loss) |
| GT4 | 15 | Mesenteric lymph nodes, metastases to kidneys, lungs, liver, and spleen |
| GT5 | 23 | Paraspinal area (killed because of hind limb paralysis and severe weight loss) |
| GT6 | 23 | Mesenteric lymph nodes, metastases to kidneys, lungs, and spleen |
| GT7 | >29 | — |