AlloBMT for AML in CR1: Significant Prognostic Factors in Univariate Analysis
| . | . | Relapse (SE) . | LFS (SE) . | Survival (SE) . |
|---|---|---|---|---|
| Cytogenetics | Good | 0.09 (0.04) | 0.67 (0.06) | 0.68 (0.06) |
| Standard | 0.25 (0.02) | 0.57 (0.02) | 0.59 (0.02) | |
| Poor | 0.61 (0.09) | 0.29 (0.07) | 0.32 (0.07) | |
| P | .000001 | .0005 | .0002 | |
| FAB | M1, 2, 3, 4, 7 | 0.23 (0.02) | 0.60 (0.02) | 0.62 (0.02) |
| M5, 6 | 0.43 (0.07) | 0.38 (0.06) | 0.40 (0.06) | |
| P | .004 | .0007 | .001 | |
| Int D-CR | <42 d | 0.60 (0.03) | 0.62 (0.03) | |
| ≥42 d | 0.50 (0.03) | 0.52 (0.03) | ||
| P | NS | .04 | .03 | |
| Age | <32 yrs | 0.59 (0.03) | 0.63 (0.02) | |
| ≥32 yrs | 0.51 (0.03) | 0.51 (0.03) | ||
| P | NS | .03 | .003 | |
| Int CR-BMT | <87 d | 0.33 (0.03) | ||
| ≥87 d | 0.21 (0.03) | |||
| P | .01 | NS | NS | |
| Date of BMT | <1989 | 0.53 | ||
| ≥1989 | 0.62 | |||
| P | NS | NS | .03 | |
| aGVHD | Grade 2-4 | 0.51 (0.04) | ||
| Grade 0, 1 | 0.61 (0.02) | |||
| P | NS | NS | .02 | |
| cGVHD | Present | 0.12 (0.02) | 0.72 (0.03) | 0.72 (0.03) |
| Absent | 0.33 (0.03) | 0.48 (0.02) | 0.52 (0.02) | |
| P | <.0000001 | <.0000001 | .000002 |
| . | . | Relapse (SE) . | LFS (SE) . | Survival (SE) . |
|---|---|---|---|---|
| Cytogenetics | Good | 0.09 (0.04) | 0.67 (0.06) | 0.68 (0.06) |
| Standard | 0.25 (0.02) | 0.57 (0.02) | 0.59 (0.02) | |
| Poor | 0.61 (0.09) | 0.29 (0.07) | 0.32 (0.07) | |
| P | .000001 | .0005 | .0002 | |
| FAB | M1, 2, 3, 4, 7 | 0.23 (0.02) | 0.60 (0.02) | 0.62 (0.02) |
| M5, 6 | 0.43 (0.07) | 0.38 (0.06) | 0.40 (0.06) | |
| P | .004 | .0007 | .001 | |
| Int D-CR | <42 d | 0.60 (0.03) | 0.62 (0.03) | |
| ≥42 d | 0.50 (0.03) | 0.52 (0.03) | ||
| P | NS | .04 | .03 | |
| Age | <32 yrs | 0.59 (0.03) | 0.63 (0.02) | |
| ≥32 yrs | 0.51 (0.03) | 0.51 (0.03) | ||
| P | NS | .03 | .003 | |
| Int CR-BMT | <87 d | 0.33 (0.03) | ||
| ≥87 d | 0.21 (0.03) | |||
| P | .01 | NS | NS | |
| Date of BMT | <1989 | 0.53 | ||
| ≥1989 | 0.62 | |||
| P | NS | NS | .03 | |
| aGVHD | Grade 2-4 | 0.51 (0.04) | ||
| Grade 0, 1 | 0.61 (0.02) | |||
| P | NS | NS | .02 | |
| cGVHD | Present | 0.12 (0.02) | 0.72 (0.03) | 0.72 (0.03) |
| Absent | 0.33 (0.03) | 0.48 (0.02) | 0.52 (0.02) | |
| P | <.0000001 | <.0000001 | .000002 |
The data are 3-year Kaplan and Meier estimates.
Abbreviations: AlloBMT, allogeneic bone marrow transplantation; CR1, first complete remission; SE, standard error of the mean; LFS, leukemia-free survival; FAB, French-American-British classification; Int D-CR, time interval from diagnosis to complete remission; Int CR-BMT, time interval from complete remission to bone marrow transplantation; aGVHD, acute graft-versus-host disease; cGVHD, chronic graft-versus-host disease.