ICSBP-Transcript Numbers in Peripheral Blood From Normal Healthy Individuals and Patients With Different Kinds of Leukemias
| Diagnosis . | Amount of Samples . | Mean (CI 95%)* . | % Samples With Impaired ICSBP Expression† . | Fisher's Exact Test . |
|---|---|---|---|---|
| NB | 33 | 0.406 (0.350-0.462) | 6 | — |
| CML‡ | 34 | 0.113 (0.054-0.171) | 79 | P < .0001 |
| AML§ | 33 | 0.225 (0.121-0.330) | 66 | P < .0001 |
| CLL | 11 | 0.725 (0.628-0.822) | 0 | P = .5581 |
| ALL∥ | 11 | 0.322 (0.176-0.468) | 36 | P = .0269 |
| CMMoL | 6 | 0.491 (0.100-0.881) | 17 | P = .4008 |
| Diagnosis . | Amount of Samples . | Mean (CI 95%)* . | % Samples With Impaired ICSBP Expression† . | Fisher's Exact Test . |
|---|---|---|---|---|
| NB | 33 | 0.406 (0.350-0.462) | 6 | — |
| CML‡ | 34 | 0.113 (0.054-0.171) | 79 | P < .0001 |
| AML§ | 33 | 0.225 (0.121-0.330) | 66 | P < .0001 |
| CLL | 11 | 0.725 (0.628-0.822) | 0 | P = .5581 |
| ALL∥ | 11 | 0.322 (0.176-0.468) | 36 | P = .0269 |
| CMMoL | 6 | 0.491 (0.100-0.881) | 17 | P = .4008 |
Abbreviations: NB, normal healthy blood donors; CI, confidence interval.
Relative ICSBP expression is displayed as arbitrary value, calculated as ratio of the integrated optical densities (IntOD) ofICSBP- to β-actin- transcript numbers.
The cut-off for normal ICSBP expression was fixed at the arbitrary value of 0.200.
All CML patients were untreated, treated with hydroxyurea, or exhibit relapses of CML after bone marrow transplantation.
All AML patients exhibited blast counts above 75%.
∥All ALL patients exhibited blast counts above 50%.