Pretreatment Hematologic Characteristics of 221 PML-RARα–positive INT 0129 Patients as a Function of PML-RARα mRNA Type
| Characteristic or Category . | PML-RARα mRNA Type . | ||
|---|---|---|---|
| . | S-form . | L-form . | V-form . |
| Hemoglobin | |||
| ≤9 g/dL | 37 (46) | 48 (40) | 5 (28) |
| >9 g/dL | 43 (54) | 73 (60) | 13 (72) |
| Platelet count* | |||
| ≤20,000 | 31 (39) | 32 (26) | 4 (22) |
| >20,000-50,000 | 23 (29) | 47 (39) | 8 (44) |
| >50,000 | 26 (32) | 42 (36) | 6 (33) |
| WBC count† | |||
| ≤2,000 | 34 (42) | 72 (59) | 7 (39) |
| 2,000-5,000 | 11 (14) | 24 (20) | 3 (17) |
| >5,000 | 35 (44) | 25 (21) | 8 (44) |
| PB pros + blasts‡ | |||
| ≤10% | 19 (33) | 46 (53) | 3 (30) |
| >10% | 38 (67) | 41 (47) | 7 (70) |
| PB pros + blastsρ | |||
| ≤100/uL | 16 (28) | 44 (48) | 4 (36) |
| >100/uL | 41 (72) | 47 (52) | 7 (64) |
| BM pros + blasts | |||
| ≤80% | 31 (54) | 41 (54) | 6 (43) |
| >80% | 26 (46) | 35 (46) | 8 (57) |
| FAB classification2-155 | |||
| M3 | 62 (76) | 106 (88) | 15 (83) |
| M3v | 20 (24) | 15 (12) | 3 (17) |
| Characteristic or Category . | PML-RARα mRNA Type . | ||
|---|---|---|---|
| . | S-form . | L-form . | V-form . |
| Hemoglobin | |||
| ≤9 g/dL | 37 (46) | 48 (40) | 5 (28) |
| >9 g/dL | 43 (54) | 73 (60) | 13 (72) |
| Platelet count* | |||
| ≤20,000 | 31 (39) | 32 (26) | 4 (22) |
| >20,000-50,000 | 23 (29) | 47 (39) | 8 (44) |
| >50,000 | 26 (32) | 42 (36) | 6 (33) |
| WBC count† | |||
| ≤2,000 | 34 (42) | 72 (59) | 7 (39) |
| 2,000-5,000 | 11 (14) | 24 (20) | 3 (17) |
| >5,000 | 35 (44) | 25 (21) | 8 (44) |
| PB pros + blasts‡ | |||
| ≤10% | 19 (33) | 46 (53) | 3 (30) |
| >10% | 38 (67) | 41 (47) | 7 (70) |
| PB pros + blastsρ | |||
| ≤100/uL | 16 (28) | 44 (48) | 4 (36) |
| >100/uL | 41 (72) | 47 (52) | 7 (64) |
| BM pros + blasts | |||
| ≤80% | 31 (54) | 41 (54) | 6 (43) |
| >80% | 26 (46) | 35 (46) | 8 (57) |
| FAB classification2-155 | |||
| M3 | 62 (76) | 106 (88) | 15 (83) |
| M3v | 20 (24) | 15 (12) | 3 (17) |
Results are expressed as the number of cases (percent of cases).
Abbreviations: WBC, white blood cell; PB, peripheral blood; BM, bone marrow; pros, promyelocytes; FAB, French-American-British.
P = .06 ≤ 20,000 v > 20,000, S-form v L-form cases.
P = .0008 ≤ 5,000 v > 5,000, S-form v L-form cases.
P = .040 ≤ 10% v > 10%, S-form v L-form cases.
ρ P = .041 ≤ 100/uL v > 100/uL, S-form v L-form cases.
P = .036 M3 v M3v, S-form v L-form cases.