Detection of PML-RARα by Immunocytochemistry and RT-PCR in 14 APL Cases
| Case . | Sex/Age . | PG-M3 . | RT-PCR (PML/RARα) . | Bcr . | Therapy . | Response . |
|---|---|---|---|---|---|---|
| APL 1 | F/31 | +(m) | Pos. | 3 | AIDA | CR |
| APL 2 | F/29 | +(m) | Pos. | 3 | AIDA | CR |
| APL 3 | M/31 | +(m) | Pos. | 3 | AIDA | CR |
| APL 4 | F/61 | +(m) | Pos. | 1 | AIDA | CR |
| APL 5 | F/29 | +(m) | Pos. | 3 | AIDA | CR |
| APL 6 | F/62 | +(m) | Pos. | 3 | AIDA | CR |
| APL 7 | M/74 | +(m) | Pos. | 3 | ATRA | CR |
| APL 8 | F/16 | +(m) | Pos. | 1 | AIDA | CR |
| APL 9 | M/56 | +(m) | Pos. | 1 | AIDA | PR |
| APL 10 | F/42 | +(m) | Pos. | NE | AIDA | CR |
| APL 11 | M/31 | +(m) | Pos. | 1 | AIDA | CR |
| APL 12 | F/12 | +(m) | Pos. | 3 | AIDA | CR |
| APL 13 | F/46 | +(m) | Pos. | 1 | AIDA | CR |
| APL 14 | F/40 | +(m) | Pos. | 2 | AIDA | CR |
| Case . | Sex/Age . | PG-M3 . | RT-PCR (PML/RARα) . | Bcr . | Therapy . | Response . |
|---|---|---|---|---|---|---|
| APL 1 | F/31 | +(m) | Pos. | 3 | AIDA | CR |
| APL 2 | F/29 | +(m) | Pos. | 3 | AIDA | CR |
| APL 3 | M/31 | +(m) | Pos. | 3 | AIDA | CR |
| APL 4 | F/61 | +(m) | Pos. | 1 | AIDA | CR |
| APL 5 | F/29 | +(m) | Pos. | 3 | AIDA | CR |
| APL 6 | F/62 | +(m) | Pos. | 3 | AIDA | CR |
| APL 7 | M/74 | +(m) | Pos. | 3 | ATRA | CR |
| APL 8 | F/16 | +(m) | Pos. | 1 | AIDA | CR |
| APL 9 | M/56 | +(m) | Pos. | 1 | AIDA | PR |
| APL 10 | F/42 | +(m) | Pos. | NE | AIDA | CR |
| APL 11 | M/31 | +(m) | Pos. | 1 | AIDA | CR |
| APL 12 | F/12 | +(m) | Pos. | 3 | AIDA | CR |
| APL 13 | F/46 | +(m) | Pos. | 1 | AIDA | CR |
| APL 14 | F/40 | +(m) | Pos. | 2 | AIDA | CR |
Abbreviations: bcr, breakpoint region; CR, complete remission; PR, partial remission; NE, not established; (m), microgranular; AIDA, all-trans retinoic acid (ATRA) + Idarubicin (IDA).
Cases 1-5 were investigated retrospectively on frozen cell samples.