Table 3. Characterization and Response... | American Society of Hematology

Table 3.

Characterization and Response to Interferon Therapy of Liver Disease in Patients With HCV-Associated Cryoglobulinemia

Patient No.	Response of Cryoglobulinemia	Liver Histology^3-150	HCV Genotype	Initial ALT^3-151	Total Dose of Interferon	Relapse of Abnormal ALT	Months Off-Therapy With Normal ALT
1	Complete	ND	1a	37	729	No	100
6	Complete	6 + 1	1b	36	717	No	53
9	Complete	ND	1b	30	814	No	17
10	Complete	5 + 2	1a	38	621	No	62
11	Complete	ND	2b	105	621	No	46
12	Complete	4 + 2	ND	108	621	No	33
13	Complete	5 + 2	2b	79	468	Yes	3
14	Complete	4 + 1	1a	64	621	No	18
15	Complete	ND	1b	70	621	No	16
16	Complete	9 + 4	2b	66	315	No	Lost to follow-up
19	Minor	2 + 1	ND	48	847	No	60
22	Minor	ND	1b	85	814	No	96
23	Minor	ND	1b	97	621	No	77
24	Minor	4 + 2	1b	47	814	Yes	6
26	Minor	ND	1b	125	234	Yes	1
27	Minor	5 + 1	1b	147	234	Yes	1
28	Minor	ND	2b	35	234	Yes	3
30	Minor	ND	2b	61	621	No	60

Patient No.	Response of Cryoglobulinemia	Liver Histology^3-150	HCV Genotype	Initial ALT^3-151	Total Dose of Interferon	Relapse of Abnormal ALT	Months Off-Therapy With Normal ALT
1	Complete	ND	1a	37	729	No	100
6	Complete	6 + 1	1b	36	717	No	53
9	Complete	ND	1b	30	814	No	17
10	Complete	5 + 2	1a	38	621	No	62
11	Complete	ND	2b	105	621	No	46
12	Complete	4 + 2	ND	108	621	No	33
13	Complete	5 + 2	2b	79	468	Yes	3
14	Complete	4 + 1	1a	64	621	No	18
15	Complete	ND	1b	70	621	No	16
16	Complete	9 + 4	2b	66	315	No	Lost to follow-up
19	Minor	2 + 1	ND	48	847	No	60
22	Minor	ND	1b	85	814	No	96
23	Minor	ND	1b	97	621	No	77
24	Minor	4 + 2	1b	47	814	Yes	6
26	Minor	ND	1b	125	234	Yes	1
27	Minor	5 + 1	1b	147	234	Yes	1
28	Minor	ND	2b	35	234	Yes	3
30	Minor	ND	2b	61	621	No	60

Abbreviation: ND, not determined.

F3-150

Histological activity is expressed by the Knodell score¹²; the first number refers to grading (scores 1 + 2 + 3), and the second to staging (score 4).

F3-151

Highest ALT value observed within 3 months before the initiation of therapy; normal values <22 U/L.

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