Analysis of IgG Biosynthetic Rates in Mice Differing in IgG Levels Because of Increased Catabolism
| . | t (days) . | k10 (day−1) . | CSS [IgG] (μg/mL) . | q (μg/mL/d) . |
|---|---|---|---|---|
| Wild-type | 3.78 | 0.18 ± .01 | 2200 ± 100 | 396 ± 28 |
| FcRp knockout | 0.52 | 1.34 ± .06 | 260 ± 30 | 348 ± 43 |
| NS; P > .1 |
| . | t (days) . | k10 (day−1) . | CSS [IgG] (μg/mL) . | q (μg/mL/d) . |
|---|---|---|---|---|
| Wild-type | 3.78 | 0.18 ± .01 | 2200 ± 100 | 396 ± 28 |
| FcRp knockout | 0.52 | 1.34 ± .06 | 260 ± 30 | 348 ± 43 |
| NS; P > .1 |
The listed t value is for the catabolic t , not the β t . Errors on k10 are derived from the fitting program of the average data and errors on the [IgG] are derived from the individual mouse plasma levels. There were 5 mice per group. The standard error of the product (q = k10 CSS) is derived by standard formulas. Statistical significance is determined by the two-tailed Student's t-test. Derived from Junghans and Anderson.12
Abbreviation: NS, not significant.