Table 1. Germline and Rearranged V H and... | American Society of Hematology

Table 1.

Germline and Rearranged V_H and V_L Gene Segments Used in Anti-Rh(D) H and L Chains

Family	Antibody^*	Isotype	Probable† Germline V Gene	Nucleotide Differences	Next closest† Germline V Gene	Nucleotide Differences	Closest† Rearranged V Gene	Nucleotide Differences
V_H1	25F5	IgG1/k	V1-2	8	DP-8	9	20P3 fetal	7
V_H1	13E10	IgG1/λ	V1-2	12	DP-8	13	20P3 fetal	13
V_H1	21H9	IgG1/k	DP-25	11	VI-3	16	LE 1-42 fetal	11
V_H1	28E4	IgG1/k	DP-7	14	HG3	15	H20C3H fetal	16
V_H3	24A5	IgG3/λ	hv3019b9	5	P6	7	FL13-48 fetal	5
V_H3	26C1	IgG3/k	hv3019b9	5	P6	7	FL13-48 fetal	5
V_H3	19A5	IgG1/k	hv3019b9	17	P6	19	FL13-48 fetal	17
V_H3	43F10	IgG1/k	hv3019b9	16	P6	18	FL13-48 fetal	16
V_H3	13D2	IgG3/k	hv3019b13	9	DP-46	10	M74 fetal	9
V_H3	46E7	IgG1/k	3-21	16	3-48	20	E54 fetal	13
V_kI	26C1	IgG3/k	L11	10	A30	21	2E7 anti-platelet	18
V_kI	13D2	IgG3/k	02	8	L11	23	15a anti-i	5
V_kI	21H9	IgG1/k	02	12	L11	27	15a anti-i	12
V_kI	43F10	IgG1/k	02	13	L11	29	15a anti-i	13
V_kI	46E7	IgG1/k	L12a	6	HK102	10	I.26	6
V_kI	25F5	IgG1/k	L12a	15	HK102	19	I.26	10
V_kIII	28E4	IgG1/k	DPK21	2	Vg	19	Z18330^‡	2
V_kIII	19A5	IgG1/k	Humkv325	7	Humvk305	12	T15-42	6
V_λII	13E10	IgG1/λ	DPL-11	2	DP-L10	16	L25295^‡	2
V_λIV	24A5	IgG3/λ	IGLV3S1	12	Vλ III.1	73	E51	10

Family	Antibody^*	Isotype	Probable† Germline V Gene	Nucleotide Differences	Next closest† Germline V Gene	Nucleotide Differences	Closest† Rearranged V Gene	Nucleotide Differences
V_H1	25F5	IgG1/k	V1-2	8	DP-8	9	20P3 fetal	7
V_H1	13E10	IgG1/λ	V1-2	12	DP-8	13	20P3 fetal	13
V_H1	21H9	IgG1/k	DP-25	11	VI-3	16	LE 1-42 fetal	11
V_H1	28E4	IgG1/k	DP-7	14	HG3	15	H20C3H fetal	16
V_H3	24A5	IgG3/λ	hv3019b9	5	P6	7	FL13-48 fetal	5
V_H3	26C1	IgG3/k	hv3019b9	5	P6	7	FL13-48 fetal	5
V_H3	19A5	IgG1/k	hv3019b9	17	P6	19	FL13-48 fetal	17
V_H3	43F10	IgG1/k	hv3019b9	16	P6	18	FL13-48 fetal	16
V_H3	13D2	IgG3/k	hv3019b13	9	DP-46	10	M74 fetal	9
V_H3	46E7	IgG1/k	3-21	16	3-48	20	E54 fetal	13
V_kI	26C1	IgG3/k	L11	10	A30	21	2E7 anti-platelet	18
V_kI	13D2	IgG3/k	02	8	L11	23	15a anti-i	5
V_kI	21H9	IgG1/k	02	12	L11	27	15a anti-i	12
V_kI	43F10	IgG1/k	02	13	L11	29	15a anti-i	13
V_kI	46E7	IgG1/k	L12a	6	HK102	10	I.26	6
V_kI	25F5	IgG1/k	L12a	15	HK102	19	I.26	10
V_kIII	28E4	IgG1/k	DPK21	2	Vg	19	Z18330^‡	2
V_kIII	19A5	IgG1/k	Humkv325	7	Humvk305	12	T15-42	6
V_λII	13E10	IgG1/λ	DPL-11	2	DP-L10	16	L25295^‡	2
V_λIV	24A5	IgG3/λ	IGLV3S1	12	Vλ III.1	73	E51	10

21H9 and 19A5 MoAbs were derived of the peripheral blood lymphocytes (PBLs) of donor LA and the other MoAbs of the PBLs of donor AR.

†

References for germline and rearranged genes are as follows: Germline V_H: VI-2 and VI-3²¹; DP-25, DP7, DP-8 and DP-46²²; hv3019b9 and hv3019b13²³; 3-21 and 3-48²⁴; HG3²⁵. Rearranged V_H 20P3²⁶; LE 1-42²⁷; H20C3H²⁸; FL13-48²⁹; M74,30 and E54³¹. Germline V_L: L11³²; 02³³; L12a and A30³⁴; DPK21³⁵; Humkv325³⁶; HK102³⁷; Humvk305³⁸; Vg³⁹; DPL-11 and DPL-10⁴⁰; IGLV3S141 and VλIII.1.42 Rearranged V_L: 2E7⁴³; 15a⁴⁴; I.26⁴⁵; T15-42⁴⁶; L25295,47 and E51.48

‡

Genbank accession number.

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