Effect of Unfractionated Heparin and the LMWH, Tinzaparin, on Trabecular Thickness, Number, and Separation
| . | Trabecular . | Trabecular . | Trabecular . |
|---|---|---|---|
| . | Width (μm) . | No. (no./mm2 ) . | Separation (μm) . |
| Baseline | 63.2 ± 1.7 | 11.0 ± 0.6 | 101.2 ± 8.2 |
| Control | 60.5 ± 3.7 | 10.2 ± 0.5 | 110.9 ± 7.6 |
| LMWH (0.5 U/g) | 58.2 ± 2.9 | 7.9 ± 0.3* | 147.8 ± 10.7* |
| LMWH (1.0 U/g) | 54.4 ± 0.5* | 8.0 ± 0.2* | 157.7 ± 4.4* |
| Heparin (0.5 U/g) | 57.5 ± 1.0 | 7.2 ± 0.2*† | 164.8 ± 12.4* |
| Heparin (1.0 U/g) | 49.1 ± 1.6*† | 7.1 ± 0.3*† | 172.8 ± 6.0*† |
| . | Trabecular . | Trabecular . | Trabecular . |
|---|---|---|---|
| . | Width (μm) . | No. (no./mm2 ) . | Separation (μm) . |
| Baseline | 63.2 ± 1.7 | 11.0 ± 0.6 | 101.2 ± 8.2 |
| Control | 60.5 ± 3.7 | 10.2 ± 0.5 | 110.9 ± 7.6 |
| LMWH (0.5 U/g) | 58.2 ± 2.9 | 7.9 ± 0.3* | 147.8 ± 10.7* |
| LMWH (1.0 U/g) | 54.4 ± 0.5* | 8.0 ± 0.2* | 157.7 ± 4.4* |
| Heparin (0.5 U/g) | 57.5 ± 1.0 | 7.2 ± 0.2*† | 164.8 ± 12.4* |
| Heparin (1.0 U/g) | 49.1 ± 1.6*† | 7.1 ± 0.3*† | 172.8 ± 6.0*† |
Rats were injected daily with vehicle alone or either LMWH and/or unfractionated heparin, at doses of 0.5 and 1.0 U/g, and the region extending from the epiphyseal growth plate and including the entire metaphysis was analyzed at day 32 for: (1) trabecular width; (2) trabecular number and; (3) trabecular separation. Data are expressed as mean ± SEM.
P < .005 when compared with either baseline or control values.
P < .01 when compared with values obtained from LMWH-treated animals.