Effect of Unfractionated Heparin and the LMWH, Tinzaparin, on Serum Alkaline Phosphatase Levels
| . | Serum Alkaline Phosphatase . | ||
|---|---|---|---|
| . | (U/L) . | . | |
| . | Day 0 . | Day 32 . | . |
| Control | 79.5 ± 7.1 | 75.0 ± 5.5 | |
| LMWH (0.5 U/g) | 81.4 ± 6.8 | 61.3 ± 3.4*† | |
| LMWH (1.0 U/g) | 86.0 ± 3.0 | 51.7 ± 4.5*† | |
| Heparin (0.5 U/g) | 87.5 ± 5.2 | 63.3 ± 4.8*† | |
| Heparin (1.0 U/g) | 84.8 ± 6.5 | 59.1 ± 6.2*† | |
| . | Serum Alkaline Phosphatase . | ||
|---|---|---|---|
| . | (U/L) . | . | |
| . | Day 0 . | Day 32 . | . |
| Control | 79.5 ± 7.1 | 75.0 ± 5.5 | |
| LMWH (0.5 U/g) | 81.4 ± 6.8 | 61.3 ± 3.4*† | |
| LMWH (1.0 U/g) | 86.0 ± 3.0 | 51.7 ± 4.5*† | |
| Heparin (0.5 U/g) | 87.5 ± 5.2 | 63.3 ± 4.8*† | |
| Heparin (1.0 U/g) | 84.8 ± 6.5 | 59.1 ± 6.2*† | |
Rats were injected with either unfractionated heparin or LMWH at a concentration of either 0.5 anti-Xa U/g or 1.0 anti-Xa U/g. One group of rats also served as a control and were given equivalent volumes of saline instead of heparin. Serum samples were taken at days 0 and 32 from both treated and nontreated rats and assayed for alkaline phosphatase activity. Data are expressed as mean ± SEM.
P < .001 when compared with control values at day 32.
P < .005 when compared with baseline values at day 0.