Prior Treatment Characteristics
| Patient . | Cohort . | Initial Regimen . | Salvage Regimen 1 . | Salvage Regimen 2 . | Extensive Prior . |
|---|---|---|---|---|---|
| . | . | . | . | . | Chemotherapy4-151 . |
| 102 | A | CHOP × 8 | DHAP × 2 | Y | |
| 107 | A | PROMACE-CYTABOM × 4 | CHOP × 2 | N | |
| 110 | A | CHOP × 2 | DHAP × 2 | Y | |
| 203 | A | MACOP-B × 3 | CHOP × 3 | N | |
| 205 | A | CHOP × 4 | DHAP × 1 | N | |
| 208 | A | CHOP × 12 | ICE × 3 | N | |
| 301 | A | CHOP × 8 | DHAP × 2 | Y | |
| 307 | A | CHOP × 6 | Radiation4-150 | N | |
| 400 | A | PROMACE-CYTABOM × 6 | ICE × 3 | MTX/HIDARA-C × 5 | Y |
| 407 | A | CHOP × 6 | DHAP × 2 | ICE × 3 | Y |
| 101 | B | PROMACE-CYTABAM × 4 | ICE × 2 | N | |
| 103 | B | CHOP × 4 | DHAP × 2 | Y | |
| 104 | B | CHOP × 4 | DHAP × 2 | Y | |
| 105 | B | CHOP × 4 | DHAP × 2 | Y | |
| 108 | B | CHOP × 8 | DHAP × 2 | Y | |
| 109 | B | DOX, VCR × 4 | ICE × 2 | N | |
| 201 | C | CHOP × 4 | DHAP × 3 | Y | |
| 202 | C | CHOP × 6 | ICE × 2 | N | |
| 204 | C | MACOP-B × 3 | ICE × 2 | N | |
| 206 | C | CHOPE × 2 | DHAP × 2 | Y | |
| 207 | C | ABVD × 5 | ICE × 2 | EPOCH × 1 | N |
| 209 | C | CHOP × 6 | ICE × 3 | MTX/HIDARA-C × 5 | Y |
| 300 | D | NHL-15 | ICE × 3 | MTX/HIDARA-C × 5 | Y |
| 302 | D | CHOP × 4 | ESHAP × 1 | N | |
| 303 | D | CHOP 2 | CHOP × 4 | N | |
| 304 | D | PROMACE-MOPP × 4 | ICE × 3 | Y | |
| 305 | D | CVP × 8 | COPBLAM × 4 | Y | |
| 306 | D | NHL-15 | ICE × 3 | MTX/HIDARA-C × 5 | Y |
| 308 | D | CHOP × 6 | ICE × 3 | MTX/HIDARA-C × 5 | Y |
| 401 | E | CHOP-BLEO × 3 | Dexa-BEAM × 2 | Y | |
| 402 | E | NHL-15 | ICE × 3 | MTX/HIDARA-C × 5 | Y |
| 403 | E | CHOP × 6 | ICE × 3 | MTX/HIDARA-C × 5 | Y |
| 404 | E | NHL-15 | ICE × 3 | MTX/HIDARA-C × 5 | Y |
| 405 | E | NHL-15 | ICE × 3 | MTX/HIDARA-C × 5 | Y |
| 406 | E | CHOP × 6 | CHOP × 4 | C-MOPP × 4 | Y |
| 407 | E | CHOP × 6 | DHAP × 2 | ICE × 3 | Y |
| 408 | E | CHOP × 6 | MOPP × 6 | DHAP × 1/HD CTX | Y |
| Patient . | Cohort . | Initial Regimen . | Salvage Regimen 1 . | Salvage Regimen 2 . | Extensive Prior . |
|---|---|---|---|---|---|
| . | . | . | . | . | Chemotherapy4-151 . |
| 102 | A | CHOP × 8 | DHAP × 2 | Y | |
| 107 | A | PROMACE-CYTABOM × 4 | CHOP × 2 | N | |
| 110 | A | CHOP × 2 | DHAP × 2 | Y | |
| 203 | A | MACOP-B × 3 | CHOP × 3 | N | |
| 205 | A | CHOP × 4 | DHAP × 1 | N | |
| 208 | A | CHOP × 12 | ICE × 3 | N | |
| 301 | A | CHOP × 8 | DHAP × 2 | Y | |
| 307 | A | CHOP × 6 | Radiation4-150 | N | |
| 400 | A | PROMACE-CYTABOM × 6 | ICE × 3 | MTX/HIDARA-C × 5 | Y |
| 407 | A | CHOP × 6 | DHAP × 2 | ICE × 3 | Y |
| 101 | B | PROMACE-CYTABAM × 4 | ICE × 2 | N | |
| 103 | B | CHOP × 4 | DHAP × 2 | Y | |
| 104 | B | CHOP × 4 | DHAP × 2 | Y | |
| 105 | B | CHOP × 4 | DHAP × 2 | Y | |
| 108 | B | CHOP × 8 | DHAP × 2 | Y | |
| 109 | B | DOX, VCR × 4 | ICE × 2 | N | |
| 201 | C | CHOP × 4 | DHAP × 3 | Y | |
| 202 | C | CHOP × 6 | ICE × 2 | N | |
| 204 | C | MACOP-B × 3 | ICE × 2 | N | |
| 206 | C | CHOPE × 2 | DHAP × 2 | Y | |
| 207 | C | ABVD × 5 | ICE × 2 | EPOCH × 1 | N |
| 209 | C | CHOP × 6 | ICE × 3 | MTX/HIDARA-C × 5 | Y |
| 300 | D | NHL-15 | ICE × 3 | MTX/HIDARA-C × 5 | Y |
| 302 | D | CHOP × 4 | ESHAP × 1 | N | |
| 303 | D | CHOP 2 | CHOP × 4 | N | |
| 304 | D | PROMACE-MOPP × 4 | ICE × 3 | Y | |
| 305 | D | CVP × 8 | COPBLAM × 4 | Y | |
| 306 | D | NHL-15 | ICE × 3 | MTX/HIDARA-C × 5 | Y |
| 308 | D | CHOP × 6 | ICE × 3 | MTX/HIDARA-C × 5 | Y |
| 401 | E | CHOP-BLEO × 3 | Dexa-BEAM × 2 | Y | |
| 402 | E | NHL-15 | ICE × 3 | MTX/HIDARA-C × 5 | Y |
| 403 | E | CHOP × 6 | ICE × 3 | MTX/HIDARA-C × 5 | Y |
| 404 | E | NHL-15 | ICE × 3 | MTX/HIDARA-C × 5 | Y |
| 405 | E | NHL-15 | ICE × 3 | MTX/HIDARA-C × 5 | Y |
| 406 | E | CHOP × 6 | CHOP × 4 | C-MOPP × 4 | Y |
| 407 | E | CHOP × 6 | DHAP × 2 | ICE × 3 | Y |
| 408 | E | CHOP × 6 | MOPP × 6 | DHAP × 1/HD CTX | Y |
Abbreviations: CHOP, cyclophosphamide, doxorubicin, vincristine, and prednisone; PROMACE-CytaBOM, prednisone, cyclophosphamide, doxorubicin etoposide, ara-c, bleomycin, vincristine, methotrexate; MACOP-B, methotrexate, cyclophosphamide, doxorubicin, vincristine prednisone, bleomycin, COPBLAM, cytoxan, vincristine, procarbazine, bleomycin, leucovorin, doxorubicin, methotrexate; ABVD, doxorubicin, bleomycin, vinblastine, dacarbazine; NHL-15, doxorubicin, vincristine, high-dose cyclophosphamide; CVP, cyclophosphamide, vincristine, prednisone; DHAP, decadron, high-dose ara-c, cisplatin; ICE, ifosfamide, carboplatin, etoposide; PROMACE-MOPP, prednisone, cyclophosphamide, doxorubicin etoposide, nitrogen mustard, vincristine, procarbazine; Dexa-BEAM, decadron, carmustine, etoposide ara-c, melphalan; EPOCH, infusional CHOP plus etoposide; MTX/HIDARA-C, methotrexate, high-dose Ara-C; ESHAP, etoposide, solumedrol, ARA-C, cisplatin.
The salvage regimen for patient 307 consisted of surgical resection and radiation therapy for a local recurrence in his neck.
Patients were defined as having received extensive prior chemotherapy if they had received 2 or more cycles of any of the following drugs: procarbazine, nitrogen mustard, nitrosoureas (including BCNU), melphalan, or high-dose cytosine arabinoside (defined as ≥7.5 g).