Time to ANC and Platelet Engraftment of 0.5 × 109/L and 1.0 × 109/L by Treatment Cohort
| Treatment Cohort . | A . | B . | C . | D . | E . | |
|---|---|---|---|---|---|---|
| r-metHuSCF ( μg/kg/d) | 0 | 5 | 10 | 15 | 20 | |
| Filgrastim ( μg/kg/d) | 10 | 10 | 10 | 10 | 10 | |
| (N = 10) | (N = 6) | (N = 6) | (N = 7) | (N = 6) | Total | |
| (N = 35) | ||||||
| ANC engraftment* to: | ||||||
| 0.5 × 109/L (d) | ||||||
| Median | 9.5 | 10 | 10 | 9 | 11.5 | 10 |
| Range | (9-14) | (8-17) | (10-11) | (8-11) | (9-13) | (8-17) |
| 1.0 × 109/L (d) | ||||||
| Median | 10 | 10 | 11 | 10 | 12 | 10 |
| Range | (9-15) | (8-20) | (10-12) | (8-12) | (9-14) | (8-20) |
| Platelet engraftment† to: | ||||||
| 20 × 109/L (d) | ||||||
| Median | 12.5 | 13 | 12 | 10 | 13.5 | 12 |
| Range | (10-42) | (11-26) | (9-15) | (8-15) | (9-37) | (8-42) |
| 50 × 109/L (d) | ||||||
| Median | 16 | 16 | 15 | 14 | 21.5 | 15 |
| Range | (12-193) | (13-30) | (12-22) | (10-17) | (10-66) | (10-193) |
| Treatment Cohort . | A . | B . | C . | D . | E . | |
|---|---|---|---|---|---|---|
| r-metHuSCF ( μg/kg/d) | 0 | 5 | 10 | 15 | 20 | |
| Filgrastim ( μg/kg/d) | 10 | 10 | 10 | 10 | 10 | |
| (N = 10) | (N = 6) | (N = 6) | (N = 7) | (N = 6) | Total | |
| (N = 35) | ||||||
| ANC engraftment* to: | ||||||
| 0.5 × 109/L (d) | ||||||
| Median | 9.5 | 10 | 10 | 9 | 11.5 | 10 |
| Range | (9-14) | (8-17) | (10-11) | (8-11) | (9-13) | (8-17) |
| 1.0 × 109/L (d) | ||||||
| Median | 10 | 10 | 11 | 10 | 12 | 10 |
| Range | (9-15) | (8-20) | (10-12) | (8-12) | (9-14) | (8-20) |
| Platelet engraftment† to: | ||||||
| 20 × 109/L (d) | ||||||
| Median | 12.5 | 13 | 12 | 10 | 13.5 | 12 |
| Range | (10-42) | (11-26) | (9-15) | (8-15) | (9-37) | (8-42) |
| 50 × 109/L (d) | ||||||
| Median | 16 | 16 | 15 | 14 | 21.5 | 15 |
| Range | (12-193) | (13-30) | (12-22) | (10-17) | (10-66) | (10-193) |
Time to ANC engraftment: The number of days between PBPC infusion and the first of 2 consecutive days of ANC ≥0.5 × 109/L and ≥1.0 × 109/L (after the ANC nadir ≤0.5 × 109/L).
† Time to platelet engraftment: The number of days between PBPC infusion and the first of 2 consecutive days of platelets ≥20 × 109/L and ≥50 × 109/L (after platelet nadir ≤20 × 109/L) after PBPC infusion and at least 48 hours after any platelet transfusion support.