Table 3.

Risk Factors for Neutropenia in Multivariate Analysis

RR95% CIP Value
 
Factors significant in the final model 
Marrow cellularity day 21 
0-35% 2.44 1.53-3.89 .0002 
>35%3-150 13-151   
Max. bilirubin before day 20 
<6 mg/dL3-150 13-151   
≥6 mg/dL 2.49 1.59-3.91 .0001 
Max. serum-creatinine after day 20 
<2 mg/dL3-150 13-151   
≥2 mg/dL 2.12 1.43-3.37 .0013 
Factors not significant3-152 
Disease status 
Not advanced 13-151   
Advanced 1.31 0.83-2.09 .24 
GVHD prophylaxis 
Steroids    
No 13-151   
Yes .81 0.62-1.06 .14 
MTX 
No 13-151   
Yes .62 0.37-1.04 .08 
Time of platelet engraftment 
<Median 13-151   
>Median 1.13 0.89-1.45 .31 
Max. serum-creatinine < day 20 
<1.2 mg/dL3-150 13-151   
>1.2 mg/dL3-150 1.33 0.76-2.21 .33 
Max. serum-bilirubin > day 20 
<2 mg/dL 13-151   
≥6 mg/dL 1.19 0.58-2.44 .63 
Acute GVHD 
Grade 0-2 13-151   
Grade 3-4 1.41 0.89-2.25 .14 
RR95% CIP Value
 
Factors significant in the final model 
Marrow cellularity day 21 
0-35% 2.44 1.53-3.89 .0002 
>35%3-150 13-151   
Max. bilirubin before day 20 
<6 mg/dL3-150 13-151   
≥6 mg/dL 2.49 1.59-3.91 .0001 
Max. serum-creatinine after day 20 
<2 mg/dL3-150 13-151   
≥2 mg/dL 2.12 1.43-3.37 .0013 
Factors not significant3-152 
Disease status 
Not advanced 13-151   
Advanced 1.31 0.83-2.09 .24 
GVHD prophylaxis 
Steroids    
No 13-151   
Yes .81 0.62-1.06 .14 
MTX 
No 13-151   
Yes .62 0.37-1.04 .08 
Time of platelet engraftment 
<Median 13-151   
>Median 1.13 0.89-1.45 .31 
Max. serum-creatinine < day 20 
<1.2 mg/dL3-150 13-151   
>1.2 mg/dL3-150 1.33 0.76-2.21 .33 
Max. serum-bilirubin > day 20 
<2 mg/dL 13-151   
≥6 mg/dL 1.19 0.58-2.44 .63 
Acute GVHD 
Grade 0-2 13-151   
Grade 3-4 1.41 0.89-2.25 .14 
F3-150

Categories pooled in multivariate analysis.

F3-151

Reference category.

F3-152

Values if factor added to final model.

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