Table 2. Malarial Receptor/Adhesion... | American Society of Hematology

Table 2.

Malarial Receptor/Adhesion Proteins: Potential Targets of Receptor/Adhesion Blocking Immunity

Parasite	Receptor/Adhesion Protein	Location	Host Counter Receptor
P knowlesi	135-kD Duffy binding protein (for invasion)	Merozoite^*	Duffy glycoprotein (DARC) on RBCs
P vivax	140-kD Duffy binding protein (for invasion)	Merozoites	Duffy glycoprotein (DARC) on RBCs
P falciparum^†	170-kD Erythrocyte binding protein (for invasion)	Merozoites	Sialic Acid-glycophorin A on RBCs
P falciparum	var gene products (for sequestration)	Membrane of infected RBCs	CD36, ICAM, VCAM, E-selectin (? thrombospondin) on endothelial cells

Parasite	Receptor/Adhesion Protein	Location	Host Counter Receptor
P knowlesi	135-kD Duffy binding protein (for invasion)	Merozoite^*	Duffy glycoprotein (DARC) on RBCs
P vivax	140-kD Duffy binding protein (for invasion)	Merozoites	Duffy glycoprotein (DARC) on RBCs
P falciparum^†	170-kD Erythrocyte binding protein (for invasion)	Merozoites	Sialic Acid-glycophorin A on RBCs
P falciparum	var gene products (for sequestration)	Membrane of infected RBCs	CD36, ICAM, VCAM, E-selectin (? thrombospondin) on endothelial cells

135-kD Duffy binding protein has been localized to apical organelles (micronemes) of the merozoite.

The 170-kD erythrocyte binding protein and the var gene products of P falciparum contain Duffy binding-like domains.