Therapeutic Responses and Clinical Courses of Myeloid/NK Cell Precursor Acute Leukemia Cases
| Case No. . | Age (yr)/Sex . | Initial Therapy . | Response . | Subsequent Therapy and Clinical Course . | Survival (mo) . |
|---|---|---|---|---|---|
| 1 | 34/M | CHOP-B | PD | ||
| Received DCVP and attained CR. Relapsed in BM 6 mo after CR, and DOD. | 17 | ||||
| 2 | 46/M | Radiation, CHOP-B | NR | Received DCVP but no response. DOD. | 4 |
| 3 | 54/M | DCMP | CR | Relapsed in BM 27 mo after CR, no response to DCMP. DOD. | 30 |
| 4 | 29/F | DCMP | CR | Received allo BMT from HLA identical sibling, and died of GVHD in CR. | 19 |
| 5 | 48/M | Radiation | CR | Received chemotherapy for LBL. Relapsed in BM and testis 23 mo after CR. Attained short 2nd CR by Ara-C + ACR. DOD. | 41 |
| 6 | 19/M | CHOP-L | PR | Received DCVP and attained CR. Received allo BMT from phenotypically identical father in 1st CR. Relapsed in BM at 13 mo after CR. DOD. | 19 |
| 7 | 59/M | LDCA, DCVP | CR | Relapsed in CNS 6 mo after CR, with subsequent BM relapse. No response to high-dose Ara-C and DOD. | 11 |
| Case No. . | Age (yr)/Sex . | Initial Therapy . | Response . | Subsequent Therapy and Clinical Course . | Survival (mo) . |
|---|---|---|---|---|---|
| 1 | 34/M | CHOP-B | PD | ||
| Received DCVP and attained CR. Relapsed in BM 6 mo after CR, and DOD. | 17 | ||||
| 2 | 46/M | Radiation, CHOP-B | NR | Received DCVP but no response. DOD. | 4 |
| 3 | 54/M | DCMP | CR | Relapsed in BM 27 mo after CR, no response to DCMP. DOD. | 30 |
| 4 | 29/F | DCMP | CR | Received allo BMT from HLA identical sibling, and died of GVHD in CR. | 19 |
| 5 | 48/M | Radiation | CR | Received chemotherapy for LBL. Relapsed in BM and testis 23 mo after CR. Attained short 2nd CR by Ara-C + ACR. DOD. | 41 |
| 6 | 19/M | CHOP-L | PR | Received DCVP and attained CR. Received allo BMT from phenotypically identical father in 1st CR. Relapsed in BM at 13 mo after CR. DOD. | 19 |
| 7 | 59/M | LDCA, DCVP | CR | Relapsed in CNS 6 mo after CR, with subsequent BM relapse. No response to high-dose Ara-C and DOD. | 11 |
Abbreviations: CHOP-B, cyclophosphamide, doxorubicin, vincristine, prednisolone, and bleomycin; DCMP, daunorubicin, cytosine arabinoside, 6-mercaptopurine, and prednisolone; CHOP-L, CHOP and L-asparaginase; LDCA, low-dose cytosine arbinoside; DCVP, daunorubicin, cytosine arabinoside, vindesine, and prednisolone; CR, complete remission; PR, partial response; NR, no response; PD, progressive disease; DOD, died of disease; allo BMT, allogeneic bone marrow transplantation; HLA, human leukocyte antigen; GVHD, graft-versus-host disease; LBL, lymphoblastic lymphoma; ACR, aclarubicin.