Affinity Constants and Receptor Numbers Determined From Different PRP and 125I-rhTPO Preparations
| PRP Preparation . | Affinity (kd) . | Receptor No. . | ||
|---|---|---|---|---|
| . | Mean ± SD . | Range . | Mean ± SD . | Range . |
| Human BSC* | 605 ± 270 | 219-814 | 128 ± 54 | 79-184 |
| Human GNE† | 369 ± 50 | 319-438 | 97 ± 15 | 75-105 |
| Human GNE† | 311 ± 244 | 125-670 | 171 ± 72 | 66-224 |
| Human GNE† | 391 ± 65 | 328-472 | 34 ± 13 | 24-53 |
| WP‡ | 367 ± 151 | 260-540 | 27 ± 8 | 20-35 |
| PRP Preparation . | Affinity (kd) . | Receptor No. . | ||
|---|---|---|---|---|
| . | Mean ± SD . | Range . | Mean ± SD . | Range . |
| Human BSC* | 605 ± 270 | 219-814 | 128 ± 54 | 79-184 |
| Human GNE† | 369 ± 50 | 319-438 | 97 ± 15 | 75-105 |
| Human GNE† | 311 ± 244 | 125-670 | 171 ± 72 | 66-224 |
| Human GNE† | 391 ± 65 | 328-472 | 34 ± 13 | 24-53 |
| WP‡ | 367 ± 151 | 260-540 | 27 ± 8 | 20-35 |
Represents mean data from four separate PRP preparations obtained from Biological Specialties Co using different 125I-rhTPO preparations run at different times.
Represents mean data from three separate experiments using PRP preparations from Genentech employees (n = 4) using different 125I-rhTPO preparations run at different times.
Represents mean data from three separate washed platelet preparations from Genentech employees using different 125I-rhTPO preparations run at different times.