Characteristics of Responding and Nonresponding Patients (mean ± SD)
| Parameter . | All Patients (n = 42) . | Responding Patients . | Nonresponding Patients . | P Value* . |
|---|---|---|---|---|
| . | . | (n = 12) . | (n = 30) . | . |
| Day posttransplant of start of tPA | 17.5 ± 16.7 | 15.2 ± 15 | 18.4 ± 17.5 | .6163 |
| tPA dose, mg | 54.7 ± 28.5 | 58.3 ± 24.8 | 53.2 ± 30.1 | .5402 |
| % Weight gain 10 d before tPA | 2.8 ± 4.5 | 2.2 ± 3.4 | 3.0 ± 4.9 | .5588 |
| % Weight gain 5 d before tPA | 6.5 ± 5.2 | 6.2 ± 4.8 | 6.6 ± 5.4 | .5968 |
| % Weight gain at start of tPA | 12.5 ± 7.2 | 11.5 ± 6.9 | 12.8 ± 7.3 | .5776 |
| Total serum bilirubin 10 d before tPA (mg/dL) | 3.5 ± 4.1 | 3.1 ± 3.6 | 3.6 ± 4.3 | .7174 |
| Total serum bilirubin 5 d before tPA (mg/dL) | 6.6 ± 6.3 | 6.5 ± 6.1 | 6.6 ± 6.5 | .7488 |
| Total serum bilirubin at start of tPA (mg/dL) | 16.9 ± 8.5 | 15.2 ± 7.9 | 17.6 ± 8.7 | .3582 |
| Serum creatinine 10 d before tPA | 0.8 ± 0.3 | 0.9 ± 0.2 | 0.8 ± 0.3 | .7070 |
| Serum creatinine 5 d before tPA (mg/dL) | 1.0 ± 0.5 | 0.8 ± 0.2 | 1.0 ± 0.6 | .3278 |
| Serum creatinine at start of tPA (mg/dL) | 1.7 ± 1.2 | 1.1 ± 0.4 | 1.9 ± 1.3 | .0794 |
| No. of patients on dialysis before tPA | 6/42 | 0/12 | 6/30 | .1589 |
| No. of patients requiring O2 before tPA | 21/42 | 3/12 | 18/30 | .0855 |
| No. of patients on mechanical ventilation before start of tPA | 8/42 | 0/12 | 8/30 | .0804 |
| No. of patients on either dialysis or mechanical ventilation before start of tPA | 11/42 | 0/12 | 11/30 | .0183 |
| Parameter . | All Patients (n = 42) . | Responding Patients . | Nonresponding Patients . | P Value* . |
|---|---|---|---|---|
| . | . | (n = 12) . | (n = 30) . | . |
| Day posttransplant of start of tPA | 17.5 ± 16.7 | 15.2 ± 15 | 18.4 ± 17.5 | .6163 |
| tPA dose, mg | 54.7 ± 28.5 | 58.3 ± 24.8 | 53.2 ± 30.1 | .5402 |
| % Weight gain 10 d before tPA | 2.8 ± 4.5 | 2.2 ± 3.4 | 3.0 ± 4.9 | .5588 |
| % Weight gain 5 d before tPA | 6.5 ± 5.2 | 6.2 ± 4.8 | 6.6 ± 5.4 | .5968 |
| % Weight gain at start of tPA | 12.5 ± 7.2 | 11.5 ± 6.9 | 12.8 ± 7.3 | .5776 |
| Total serum bilirubin 10 d before tPA (mg/dL) | 3.5 ± 4.1 | 3.1 ± 3.6 | 3.6 ± 4.3 | .7174 |
| Total serum bilirubin 5 d before tPA (mg/dL) | 6.6 ± 6.3 | 6.5 ± 6.1 | 6.6 ± 6.5 | .7488 |
| Total serum bilirubin at start of tPA (mg/dL) | 16.9 ± 8.5 | 15.2 ± 7.9 | 17.6 ± 8.7 | .3582 |
| Serum creatinine 10 d before tPA | 0.8 ± 0.3 | 0.9 ± 0.2 | 0.8 ± 0.3 | .7070 |
| Serum creatinine 5 d before tPA (mg/dL) | 1.0 ± 0.5 | 0.8 ± 0.2 | 1.0 ± 0.6 | .3278 |
| Serum creatinine at start of tPA (mg/dL) | 1.7 ± 1.2 | 1.1 ± 0.4 | 1.9 ± 1.3 | .0794 |
| No. of patients on dialysis before tPA | 6/42 | 0/12 | 6/30 | .1589 |
| No. of patients requiring O2 before tPA | 21/42 | 3/12 | 18/30 | .0855 |
| No. of patients on mechanical ventilation before start of tPA | 8/42 | 0/12 | 8/30 | .0804 |
| No. of patients on either dialysis or mechanical ventilation before start of tPA | 11/42 | 0/12 | 11/30 | .0183 |
P values compare responding with nonresponding patients.