Comparison of GST Null Genotypes in Children With ALL Versus Healthy Controls
| GST Genotype . | Racial Grouping . | Odds Ratio (SE) ALL v Control . | P Value . | 95% Lower Bounds for CI for Odds Ratio3-150 . |
|---|---|---|---|---|
| GSTM1 null, GSTT1 non-null | Whites and blacks3-151 | 1.20 (0.2) | .19 | 0.87 |
| GSTT1 null, GSTM1 non-null | Whites and blacks3-151 | 1.12 (0.25) | .34 | 0.74 |
| GSTM1 null and GSTT1 null | Whites3-152 | 0.75 (0.36) | .68 | 0.35 |
| Blacks3-152 | 7.36 (1.71) | .0005 | 2.61 |
| GST Genotype . | Racial Grouping . | Odds Ratio (SE) ALL v Control . | P Value . | 95% Lower Bounds for CI for Odds Ratio3-150 . |
|---|---|---|---|---|
| GSTM1 null, GSTT1 non-null | Whites and blacks3-151 | 1.20 (0.2) | .19 | 0.87 |
| GSTT1 null, GSTM1 non-null | Whites and blacks3-151 | 1.12 (0.25) | .34 | 0.74 |
| GSTM1 null and GSTT1 null | Whites3-152 | 0.75 (0.36) | .68 | 0.35 |
| Blacks3-152 | 7.36 (1.71) | .0005 | 2.61 |
Only lower bounds estimated because comparisons were based on one-sided a priori assumptions.
Because the assumption of homogeneity of odds ratios across races was met, the Mantel-Haenszel test was used to test for the overall difference between ALL and controls.
Because the assumption of homogeneity of odds ratios across races was not met (ie, Breslow-Day test P value = .0036), the Fisher's exact test using a Bonferroni's adjustment was used to compare ALL v controls in individual race/disease strata. By race and sex, the odds ratios (SE) for children with ALL v controls was 0.63 (0.69) in white males (P = .70), 0.93 (0.58) in white females (P = .58), 7.28 (2.28) in black males (P = .0085), and 8.00 (2.80) in black females (P = .0261).