Comparison of the Removal of Iron and Porphyrin Accumulation in the Liver Induced by Hydroxypyridinone Chelators
| Treatment . | Nonheme Iron (μg/g liver) . | Ferritin . | Ferritin Iron (μg/g liver) . | Ferrochelatase Activity (nmol/h/mg) . | Protoporphyrin (nmol/g liver) . |
|---|---|---|---|---|---|
| . | . | (% of control) . | . | . | . |
| Control | 55 ± 5 | 100 ± 27 | 6.8 ± 1.4 | 12.9 ± 3.9 | 0.4 ± 0.1 |
| CP20 | 33 ± 13-150 | 72 ± 153-150 | 1.8 ± 0.33-150 | 8.2 ± 3.9 | 3.2 ± 3.9 |
| CP94 | 36 ± 23-150 | 68 ± 103-150 | 2.1 ± 0.23-150 | 8.1 ± 1.73-150 | 17.1 ± 15.93-150 |
| CP102 | 44 ± 73-150 | 78 ± 223-150 | 2.9 ± 0.63-150 | 14.9 ± 5.1 | 0.3 ± 0.1 |
| CP117 | 36 ± 23-150 | 60 ± 73-150 | 3.1 ± 0.83-150 | ND | 0.6 ± 0.1 |
| Treatment . | Nonheme Iron (μg/g liver) . | Ferritin . | Ferritin Iron (μg/g liver) . | Ferrochelatase Activity (nmol/h/mg) . | Protoporphyrin (nmol/g liver) . |
|---|---|---|---|---|---|
| . | . | (% of control) . | . | . | . |
| Control | 55 ± 5 | 100 ± 27 | 6.8 ± 1.4 | 12.9 ± 3.9 | 0.4 ± 0.1 |
| CP20 | 33 ± 13-150 | 72 ± 153-150 | 1.8 ± 0.33-150 | 8.2 ± 3.9 | 3.2 ± 3.9 |
| CP94 | 36 ± 23-150 | 68 ± 103-150 | 2.1 ± 0.23-150 | 8.1 ± 1.73-150 | 17.1 ± 15.93-150 |
| CP102 | 44 ± 73-150 | 78 ± 223-150 | 2.9 ± 0.63-150 | 14.9 ± 5.1 | 0.3 ± 0.1 |
| CP117 | 36 ± 23-150 | 60 ± 73-150 | 3.1 ± 0.83-150 | ND | 0.6 ± 0.1 |
C57BL/10 ScSn mice received CP20, CP94, and CP102 in the drinking water at 2 mg/mL and CP117 at 3 mg/mL for 2 weeks. Values are the means of 5 mice per group.
Abbreviation: ND, not determined.
Significantly different from control, P < .05.