Influence of 3-hydroxypyridin-4-ones on the Accumulation of Porphyrin Types in Livers of C57BL/10ScSn Mice
| Treatment . | Porphyrin Type and Concentration (nmol/g liver) . | ||
|---|---|---|---|
| . | Uroporphyrin . | Coproporphyrin . | Protoporphyrin . |
| Control | 0.05 ± 0.01 | 0.01 ± 0.01 | 0.27 ± 0.05 |
| CP20 | 0.04 ± 0.01 | 0.01 ± 0.00 | 0.25 ± 0.01 |
| CP94 | 0.22 ± 0.09 | 0 | 40.9 ± 13.2* |
| CP102 | 0.04 ± 0.01 | 0 | 0.32 ± 0.08 |
| Treatment . | Porphyrin Type and Concentration (nmol/g liver) . | ||
|---|---|---|---|
| . | Uroporphyrin . | Coproporphyrin . | Protoporphyrin . |
| Control | 0.05 ± 0.01 | 0.01 ± 0.01 | 0.27 ± 0.05 |
| CP20 | 0.04 ± 0.01 | 0.01 ± 0.00 | 0.25 ± 0.01 |
| CP94 | 0.22 ± 0.09 | 0 | 40.9 ± 13.2* |
| CP102 | 0.04 ± 0.01 | 0 | 0.32 ± 0.08 |
C57BL/10ScSn mice were administered CP20, CP94, or CP102 at 2 mg/mL in the drinking water for 2 weeks. Livers were analyzed by spectrofluorometry to distinguish between the three main porphyrin types as described by Grandchamp et al.17 Values are means ± SD from 3 to 6 mice per group.
Significantly different from other groups, P < .05.