Table 1.

Expression of Bcl-2 Family Genes, p53 Status, and Their Association With Sensitivity to DNA Damage Induced by IR in Pediatric ALL Cell Lines

Cell LineTypeGene Expressionp53 StatusApoptosis*
Bcl-2Bcl-xlBax
Reh EPB + + + WT − 
EU-1 EPB + + + WT − 
EU-3 PB + + + WT + 
EU-13 EPB − + + WT + 
Sup-B7 EPB − + + WT + 
Sup-B13 PB + + + WT + 
Sup-B15 PB + + + WT + 
UoC-B1 EPB + ++ + WT − 
UoC-B3 PB − + + WT + 
UoC-B4 EPB + + + WT + 
UoC-B11 EPB + + + WT + 
EU-4 AML† − +++ + − − 
EU-5 EPB − ++ + − − 
EU-8 EPB − +++ + − − 
EU-9 T − +++ + − − 
EU-12 EPB − + + − + 
Sup-B2 EPB − + + − + 
KT T − +++ + − − 
EU-2 PB − + + MUT + 
EU-6 EPB + + + MUT − 
EU-7 T − + + MUT + 
CCRF-CEM T − + + MUT − 
Cell LineTypeGene Expressionp53 StatusApoptosis*
Bcl-2Bcl-xlBax
Reh EPB + + + WT − 
EU-1 EPB + + + WT − 
EU-3 PB + + + WT + 
EU-13 EPB − + + WT + 
Sup-B7 EPB − + + WT + 
Sup-B13 PB + + + WT + 
Sup-B15 PB + + + WT + 
UoC-B1 EPB + ++ + WT − 
UoC-B3 PB − + + WT + 
UoC-B4 EPB + + + WT + 
UoC-B11 EPB + + + WT + 
EU-4 AML† − +++ + − − 
EU-5 EPB − ++ + − − 
EU-8 EPB − +++ + − − 
EU-9 T − +++ + − − 
EU-12 EPB − + + − + 
Sup-B2 EPB − + + − + 
KT T − +++ + − − 
EU-2 PB − + + MUT + 
EU-6 EPB + + + MUT − 
EU-7 T − + + MUT + 
CCRF-CEM T − + + MUT − 

Abbreviations: EPB, early pre-B ALL; PB, pre-B ALL; T, T-ALL; WT, wild type; MUT, mutant.

*

Measured by DNA fragmentation after treatment with IR (10 Gy) for 5 hours.

†

Established from a child with ALL but expressing predominantly myeloid antigens.

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