Transduction and Administration of CD4-Enriched PBL
| Animal . | Apheresis/Transduction (days between Aph/Trdx) . | Total No. of CD4+ Cells Reinfused . | No. Cells/Kg . | % Trdx . |
|---|---|---|---|---|
| RQ1114 | No. 1 | 3.5 × 108 | 5.6 × 107 | 20 |
| No. 2 (28 days) | 1.4 × 108 | 2.2 × 107 | 33 | |
| No. 3 (172 days) | 6.2 × 108 | 8.8 × 107 | 28 | |
| No. 4 (83 days) | 5.0 × 108 | 6.1× 107 | ND | |
| RQ900 | No. 1 | 0.8 × 108 | 1.4 × 107 | 30 |
| No. 2 (35 days) | 5.2 × 108 | 9.1 × 107 | 14 | |
| No. 3 (126 days) | 5.6 × 108 | 9.2 × 107 | 12 | |
| No. 4 (106 days) | 4.2 × 108 | 7.0 × 107 | ND | |
| RQ876 | No. 1 | 4.2 × 108 | 8.9 × 107 | 35 |
| No. 2 (30 days) | 3.7 × 108 | 7.6 × 107 | 25 | |
| No. 3 (148 days) | 3.3 × 108 | 5.8 × 107 | ND |
| Animal . | Apheresis/Transduction (days between Aph/Trdx) . | Total No. of CD4+ Cells Reinfused . | No. Cells/Kg . | % Trdx . |
|---|---|---|---|---|
| RQ1114 | No. 1 | 3.5 × 108 | 5.6 × 107 | 20 |
| No. 2 (28 days) | 1.4 × 108 | 2.2 × 107 | 33 | |
| No. 3 (172 days) | 6.2 × 108 | 8.8 × 107 | 28 | |
| No. 4 (83 days) | 5.0 × 108 | 6.1× 107 | ND | |
| RQ900 | No. 1 | 0.8 × 108 | 1.4 × 107 | 30 |
| No. 2 (35 days) | 5.2 × 108 | 9.1 × 107 | 14 | |
| No. 3 (126 days) | 5.6 × 108 | 9.2 × 107 | 12 | |
| No. 4 (106 days) | 4.2 × 108 | 7.0 × 107 | ND | |
| RQ876 | No. 1 | 4.2 × 108 | 8.9 × 107 | 35 |
| No. 2 (30 days) | 3.7 × 108 | 7.6 × 107 | 25 | |
| No. 3 (148 days) | 3.3 × 108 | 5.8 × 107 | ND |
Abbreviations: Aph, apheresis; Trdx, transduction; ND, not determined.