Summary of p53 Abnormalities in 19 Cases of B-PLL
| Patient No. . | 17p13 LOH . | p53 Protein* (%) . | p53 Mutation† . | |||
|---|---|---|---|---|---|---|
| . | . | . | Codon . | Nucleotide Substitutions . | Amino Acid Substitution . | Type of Mutation . |
| 1 | Yes | + (48%) | 205 | TAT→TGT | Tyr→Cys | Ts |
| 2 | Yes | ++ (51%) | 248 | CGG→CAG | Arg→Gln | Ts CpG |
| 3 | Yes | ++ (81%) | 176 | TGC→AGC | Cys→Ser | Tv |
| 4 | Yes | ++ (90%) | 275 | 27-bp DEL | In frame | |
| 5 | Yes | — | 237 | 5-bp DEL | Frameshift | |
| 6 | Yes | — | 284 | 2-bp INS | Frameshift | |
| 7 | Yes | — | 266 | GGA→GTA | Gly→Val | Tv |
| 8 | No | — | 161 | GCC→CCC | Ala→Pro | Tv |
| 9 | No | ++ (59%) | 194 | CTT→CAT | Leu→His | Tv |
| 10 | No | ++ (47%) | 293 | 35-bp DEL | Frameshift | |
| 11 | Yes | ++ (87%) | ||||
| 12 | Yes | — | ||||
| 13 | Yes | ND | ||||
| 14 | No | + (78%) | ||||
| 15 | No | — | ||||
| 16 | No | — | ||||
| 17 | No | — | ||||
| 18 | No | — | ||||
| 19 | No | ND | ||||
| Patient No. . | 17p13 LOH . | p53 Protein* (%) . | p53 Mutation† . | |||
|---|---|---|---|---|---|---|
| . | . | . | Codon . | Nucleotide Substitutions . | Amino Acid Substitution . | Type of Mutation . |
| 1 | Yes | + (48%) | 205 | TAT→TGT | Tyr→Cys | Ts |
| 2 | Yes | ++ (51%) | 248 | CGG→CAG | Arg→Gln | Ts CpG |
| 3 | Yes | ++ (81%) | 176 | TGC→AGC | Cys→Ser | Tv |
| 4 | Yes | ++ (90%) | 275 | 27-bp DEL | In frame | |
| 5 | Yes | — | 237 | 5-bp DEL | Frameshift | |
| 6 | Yes | — | 284 | 2-bp INS | Frameshift | |
| 7 | Yes | — | 266 | GGA→GTA | Gly→Val | Tv |
| 8 | No | — | 161 | GCC→CCC | Ala→Pro | Tv |
| 9 | No | ++ (59%) | 194 | CTT→CAT | Leu→His | Tv |
| 10 | No | ++ (47%) | 293 | 35-bp DEL | Frameshift | |
| 11 | Yes | ++ (87%) | ||||
| 12 | Yes | — | ||||
| 13 | Yes | ND | ||||
| 14 | No | + (78%) | ||||
| 15 | No | — | ||||
| 16 | No | — | ||||
| 17 | No | — | ||||
| 18 | No | — | ||||
| 19 | No | ND | ||||