Human T Cells Are Present in the PB of BM-SCID-hu Mice Implanted With Human Thymus
| SCID Mouse No. . | Transplanted Tissue . | % Positive Human Cells . | |||
|---|---|---|---|---|---|
| . | . | CD45 . | CD4 . | CD8 . | CD19 . |
| 1 | HFBM + thy | 33 | 14 | 5 | 4 |
| 2 | HFBM + thy | 25 | 8 | 3 | 8 |
| 3 | HFBM + thy | 7 | 2 | 1 | 5 |
| 4 | HFBM + thy | 31 | 12 | 3 | ND |
| 5 | HFL + thy | 22 | 18 | 4 | ND |
| 6 | HFL + thy | 10 | 8 | 2 | ND |
| 1 | thy | 0 | 0 | 0 | 0 |
| 2 | thy | 0.3 | 0 | 0 | 0 |
| 3 | thy | 0.3 | 0 | 0 | 0 |
| 4 | thy | 2 | 0.6 | 0.6 | 0 |
| 5 | thy | 3 | 0.6 | 0 | 0 |
| SCID Mouse No. . | Transplanted Tissue . | % Positive Human Cells . | |||
|---|---|---|---|---|---|
| . | . | CD45 . | CD4 . | CD8 . | CD19 . |
| 1 | HFBM + thy | 33 | 14 | 5 | 4 |
| 2 | HFBM + thy | 25 | 8 | 3 | 8 |
| 3 | HFBM + thy | 7 | 2 | 1 | 5 |
| 4 | HFBM + thy | 31 | 12 | 3 | ND |
| 5 | HFL + thy | 22 | 18 | 4 | ND |
| 6 | HFL + thy | 10 | 8 | 2 | ND |
| 1 | thy | 0 | 0 | 0 | 0 |
| 2 | thy | 0.3 | 0 | 0 | 0 |
| 3 | thy | 0.3 | 0 | 0 | 0 |
| 4 | thy | 2 | 0.6 | 0.6 | 0 |
| 5 | thy | 3 | 0.6 | 0 | 0 |
SCID mice were transplanted with HFBM (n = 4 mice) or HFL (n = 2 mice) and then implanted with human thymus (HFBM + thy or HFL + thy) or SCID mice (n = 5 mice) were implanted with human thymus alone (thy). Three months later the PB was assessed for the presence of human cells expressing CD45, CD4, CD8, and CD19. The mean percentage (± SEM) of cells expressing the indicated human surface marker present in the PB of the indicated SCID mouse is shown.
Abbreviation: ND, not done.