Peak Lipid and Lipoprotein Levels by Timepoint of Asparaginase Therapy
| . | Pre . | During . | Post . | LT . | ||||
|---|---|---|---|---|---|---|---|---|
| . | Mean (SD) . | Median (range) . | Mean (SD) . | Median (range) . | Mean (SD) . | Median (range) . | Mean (SD) . | Median (range) . |
| Triglyceride | 109 (45)* | 95 (48-268) | 589 (830)* | 359 (46-4520) | 79 (37)* | 79 (21-168) | 71 (44) | 63 (11-238) |
| Cholesterol | 171 (45) | 166 (83-263) | 205 (77)* | 193 (87-426) | 163 (38) | 165 (85-234) | 176 (39)† | 172 (118-278) |
| LDL | 119 (40) | 120 (50-213) | 96 (57)* | 88 (24-328) | 104 (32)* | 108 (54-163) | 118 (36) | 115 (70-221) |
| HDL | 34 (13)* | 35 (15-71) | 37 (15)* | 32 (11-72) | 47 (12)† | 46 (21-78) | 45 (13)* | 44 (24-82) |
| Apo-A1 | 139 (32) | 144 (108-196) | 123 (32) | 126 (52-164) | 128 (21) | 122 (105-181) | 136 (23) | 132 (105-198) |
| Apo-B100 | 122 (27) | 121 (88-183) | 153 (95) | 135 (54-392) | 79 (20) | 85 (47-105) | 82 (22) | 76 (44-142) |
| . | Pre . | During . | Post . | LT . | ||||
|---|---|---|---|---|---|---|---|---|
| . | Mean (SD) . | Median (range) . | Mean (SD) . | Median (range) . | Mean (SD) . | Median (range) . | Mean (SD) . | Median (range) . |
| Triglyceride | 109 (45)* | 95 (48-268) | 589 (830)* | 359 (46-4520) | 79 (37)* | 79 (21-168) | 71 (44) | 63 (11-238) |
| Cholesterol | 171 (45) | 166 (83-263) | 205 (77)* | 193 (87-426) | 163 (38) | 165 (85-234) | 176 (39)† | 172 (118-278) |
| LDL | 119 (40) | 120 (50-213) | 96 (57)* | 88 (24-328) | 104 (32)* | 108 (54-163) | 118 (36) | 115 (70-221) |
| HDL | 34 (13)* | 35 (15-71) | 37 (15)* | 32 (11-72) | 47 (12)† | 46 (21-78) | 45 (13)* | 44 (24-82) |
| Apo-A1 | 139 (32) | 144 (108-196) | 123 (32) | 126 (52-164) | 128 (21) | 122 (105-181) | 136 (23) | 132 (105-198) |
| Apo-B100 | 122 (27) | 121 (88-183) | 153 (95) | 135 (54-392) | 79 (20) | 85 (47-105) | 82 (22) | 76 (44-142) |
All values are expressed in milligrams per deciliter. Statistical comparisons are based on comparisons with published general population norms. Population norms for Apo-A1 and Apo-B100 are not available for children of all ages.
Abbreviations: Pre, before initiation of asparaginase therapy; During, during 30-week asparaginase therapy; Post, after completion of asparaginase therapy; LT, long-term survivors.
P < .01.
P < .05.