EBV Strains With Similar EBNA-2 and LMP-1 Sequences Are Carried by Neoplastic and Normal Cells of Patients With EBV-Associated Lymphoproliferative Disorders
| Case . | Diagnosis . | Tissues and Cell Lines Investigated . | EBNA-2 Subtype . | LMP-1 3′ Deletions . |
|---|---|---|---|---|
| TR-1 | T-cell–rich–B-cell NHL | 1 involved LN | 1 | — |
| 4 spontaneous LCLs from the lesion | 1 | — | ||
| 1 spontaneous LCL from PBMCs | 1 | — | ||
| HD-1 | HIV-unrelated HD | 1 pathologic LN | 2 | + (30 bp) |
| 1 spontaneous LCL from the lesion | 2 | + (30 bp) | ||
| 1 LN with reactive lymphadenopathy | 2 | + (30 bp) | ||
| HD-2 | HIV-unrelated HD | 1 pathologic LN | 1 | + (30 bp) |
| 1 spontaneous LCL from the lesion | 1 | + (30 bp) | ||
| HD-3 | HIV-unrelated HD | 2 involved LNs | 1 | + (63 bp) |
| 2 spontaneous LCLs from the lesion | 1 | + (63 bp) | ||
| 4 spontaneous LCLs from PBMCs | 1 | + (63 bp) | ||
| NH-1 | HIV-associated B-NHL (Burkitt's lymphoma) | 1 pathologic LN | Und. | + (30 bp) |
| 1 LN with LAS (synchronous) | Und. | + (30 bp) | ||
| HD-4 | HIV-associated HD | 1 involved LN | 1 | + (30 bp) |
| 1 LN with LAS (synchronous) | 1 | + (30 bp) |
| Case . | Diagnosis . | Tissues and Cell Lines Investigated . | EBNA-2 Subtype . | LMP-1 3′ Deletions . |
|---|---|---|---|---|
| TR-1 | T-cell–rich–B-cell NHL | 1 involved LN | 1 | — |
| 4 spontaneous LCLs from the lesion | 1 | — | ||
| 1 spontaneous LCL from PBMCs | 1 | — | ||
| HD-1 | HIV-unrelated HD | 1 pathologic LN | 2 | + (30 bp) |
| 1 spontaneous LCL from the lesion | 2 | + (30 bp) | ||
| 1 LN with reactive lymphadenopathy | 2 | + (30 bp) | ||
| HD-2 | HIV-unrelated HD | 1 pathologic LN | 1 | + (30 bp) |
| 1 spontaneous LCL from the lesion | 1 | + (30 bp) | ||
| HD-3 | HIV-unrelated HD | 2 involved LNs | 1 | + (63 bp) |
| 2 spontaneous LCLs from the lesion | 1 | + (63 bp) | ||
| 4 spontaneous LCLs from PBMCs | 1 | + (63 bp) | ||
| NH-1 | HIV-associated B-NHL (Burkitt's lymphoma) | 1 pathologic LN | Und. | + (30 bp) |
| 1 LN with LAS (synchronous) | Und. | + (30 bp) | ||
| HD-4 | HIV-associated HD | 1 involved LN | 1 | + (30 bp) |
| 1 LN with LAS (synchronous) | 1 | + (30 bp) |
Abbreviations: LN, lymph node; Und, undetermined.