Table 4.

Frequency of Genetic Lesions in AIDS-NHL With and Without Mutations of the 5′ Noncoding Regions of BCL-6

HistologyBCL-6c-MYC*†p53*EBV4-150
Rearrangements4-150
AIDS-BL 
With BCL-6 5′ mutations 0/11 12/12 5/12 4/12 
Without BCL-6 5′ mutations 0/5 5/5 3/5 3/8 
AIDS-DLCL 
With BCL-6 5′ mutations 3/8 0/10 1/10 5/10 
Without BCL-6 5′ mutations 0/4 2/5 0/5 3/5 
AIDS-ALCL 
With BCL-6 5′ mutations 0/2 0/2 0/2 2/2 
Without BCL-6 5′ mutations 0/1 0/1 0/1 1/1 
AIDS-BCBL 
With BCL-6 5′ mutations 0/1 0/1 0/1 1.1 
Without BCL-6 5′ mutations ND 0/4 0/4 3/4 
HistologyBCL-6c-MYC*†p53*EBV4-150
Rearrangements4-150
AIDS-BL 
With BCL-6 5′ mutations 0/11 12/12 5/12 4/12 
Without BCL-6 5′ mutations 0/5 5/5 3/5 3/8 
AIDS-DLCL 
With BCL-6 5′ mutations 3/8 0/10 1/10 5/10 
Without BCL-6 5′ mutations 0/4 2/5 0/5 3/5 
AIDS-ALCL 
With BCL-6 5′ mutations 0/2 0/2 0/2 2/2 
Without BCL-6 5′ mutations 0/1 0/1 0/1 1/1 
AIDS-BCBL 
With BCL-6 5′ mutations 0/1 0/1 0/1 1.1 
Without BCL-6 5′ mutations ND 0/4 0/4 3/4 

Abbreviations: AIDS-BL, AIDS-related Burkitt's lymphoma; AIDS-DLCL, AIDS-related diffuse large cell lymphoma; AIDS-ALCL, AIDS-related anaplastic large cell lymphoma; AIDS-BCBL, AIDS-related body-cavity-based lymphoma; ND, not done.

F4-150

Positive/tested.

F4-151

Genetic lesions of c-MYC include both gross rearrangements and mutations of c-MYC first exon-first intron border. Gross rearrangements were detected in 13 AIDS-BL and 2 AIDS-DLCL; mutations of c-MYC first exon-first intron border were detected in 5 AIDS-BL. Cases scored as positive harbored c-MYC gross rearrangements or mutations of c-MYC first exon-first intron border or both. Cases scored as negative were devoid of both c-MYC gross rearrangements and mutations of c-MYC first exon-first intron border.