Frequency of Genetic Lesions in AIDS-NHL With and Without Mutations of the 5′ Noncoding Regions of BCL-6
Histology . | BCL-6 . | c-MYC*† . | p53* . | EBV4-150 . |
---|---|---|---|---|
. | Rearrangements4-150 . | . | . | . |
AIDS-BL | ||||
With BCL-6 5′ mutations | 0/11 | 12/12 | 5/12 | 4/12 |
Without BCL-6 5′ mutations | 0/5 | 5/5 | 3/5 | 3/8 |
AIDS-DLCL | ||||
With BCL-6 5′ mutations | 3/8 | 0/10 | 1/10 | 5/10 |
Without BCL-6 5′ mutations | 0/4 | 2/5 | 0/5 | 3/5 |
AIDS-ALCL | ||||
With BCL-6 5′ mutations | 0/2 | 0/2 | 0/2 | 2/2 |
Without BCL-6 5′ mutations | 0/1 | 0/1 | 0/1 | 1/1 |
AIDS-BCBL | ||||
With BCL-6 5′ mutations | 0/1 | 0/1 | 0/1 | 1.1 |
Without BCL-6 5′ mutations | ND | 0/4 | 0/4 | 3/4 |
Histology . | BCL-6 . | c-MYC*† . | p53* . | EBV4-150 . |
---|---|---|---|---|
. | Rearrangements4-150 . | . | . | . |
AIDS-BL | ||||
With BCL-6 5′ mutations | 0/11 | 12/12 | 5/12 | 4/12 |
Without BCL-6 5′ mutations | 0/5 | 5/5 | 3/5 | 3/8 |
AIDS-DLCL | ||||
With BCL-6 5′ mutations | 3/8 | 0/10 | 1/10 | 5/10 |
Without BCL-6 5′ mutations | 0/4 | 2/5 | 0/5 | 3/5 |
AIDS-ALCL | ||||
With BCL-6 5′ mutations | 0/2 | 0/2 | 0/2 | 2/2 |
Without BCL-6 5′ mutations | 0/1 | 0/1 | 0/1 | 1/1 |
AIDS-BCBL | ||||
With BCL-6 5′ mutations | 0/1 | 0/1 | 0/1 | 1.1 |
Without BCL-6 5′ mutations | ND | 0/4 | 0/4 | 3/4 |
Abbreviations: AIDS-BL, AIDS-related Burkitt's lymphoma; AIDS-DLCL, AIDS-related diffuse large cell lymphoma; AIDS-ALCL, AIDS-related anaplastic large cell lymphoma; AIDS-BCBL, AIDS-related body-cavity-based lymphoma; ND, not done.
Positive/tested.
Genetic lesions of c-MYC include both gross rearrangements and mutations of c-MYC first exon-first intron border. Gross rearrangements were detected in 13 AIDS-BL and 2 AIDS-DLCL; mutations of c-MYC first exon-first intron border were detected in 5 AIDS-BL. Cases scored as positive harbored c-MYC gross rearrangements or mutations of c-MYC first exon-first intron border or both. Cases scored as negative were devoid of both c-MYC gross rearrangements and mutations of c-MYC first exon-first intron border.