Table 2.

Regeneration Rate Constants and Effective Doubling Times for CD4+ and CD8+ T Cells After Intensive Chemotherapy

Patient No.AgeCD4 gCD8 gCD4 Td†CD8 Td†
(yrs)(day−1)*(day−1)*(days)(days)
1 1 0.077 0.130 9 5 
2 3 0.035 0.038 20 18 
3 7 0.055 0.072 12 10 
4 8 NA NA NA NA 
5 11 0.008‡ 0.075‡ 83 9 
6 13 0.084 0.070 8 10 
7 13 NA NA NA NA 
8 14 0.026 0.050 28 14 
9 18 0.021‡ 0.091‡ 33 8 
10 19 0.035 0.037 20 19 
11 19 0.003‡ 0.003‡ 230 230 
12 21 0.010 0.010 69 69 
13 23 0.030 0.060 23 11 
14 24 0 0.010 ∞ 69 
15 24 0.024‡ 0.530‡ 29 1 
16 24 0.003 0.011 230 63 
Patient No.AgeCD4 gCD8 gCD4 Td†CD8 Td†
(yrs)(day−1)*(day−1)*(days)(days)
1 1 0.077 0.130 9 5 
2 3 0.035 0.038 20 18 
3 7 0.055 0.072 12 10 
4 8 NA NA NA NA 
5 11 0.008‡ 0.075‡ 83 9 
6 13 0.084 0.070 8 10 
7 13 NA NA NA NA 
8 14 0.026 0.050 28 14 
9 18 0.021‡ 0.091‡ 33 8 
10 19 0.035 0.037 20 19 
11 19 0.003‡ 0.003‡ 230 230 
12 21 0.010 0.010 69 69 
13 23 0.030 0.060 23 11 
14 24 0 0.010 ∞ 69 
15 24 0.024‡ 0.530‡ 29 1 
16 24 0.003 0.011 230 63 
*

The growth rate constant (g) was calculated from the equation dT/dt = gT(1-iT) where T is the number of T cells, t = time, g = growth rate constant and i = inhibitory (regulatory) constant.

†

Effective cell doubling time was calculated by 0.69/g or 0.69/g* as described in Materials and Methods.

‡

The linear growth rate constant (g*) was calculated by dividing the slopes of the linear time dependences by the initial number of cells (g* = s/a) as described in Materials and Methods.

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