Mean Specific Apoptosis Scores (%A0) for EC of Divergent Tissues Exposed to TTP Plasmas
| Tissue . | EC Sample . | No. of Experiments* . | Mean %A0 . | Range for %A0† . |
|---|---|---|---|---|
| Microvascular EC | ||||
| Lung | HMVEC-LU | 16 | 3.5 | 0-14.5 |
| Liver | HMVEC-H | 9 | 5.8 | 0-18.1 |
| Dermal | MVEC-1, -2 | 4 | 37.3 | 15.2-50.4 |
| Brain | HMVEC-B | 7 | 11.3 | 1.0-20.7 |
| Kidney | HMVEC-G | 5 (no renal disease)‡ | 9.2 | 0-15.5 |
| 3 (renal disease)‡ | 17.4 | 9.7-36.3 | ||
| Large vessel | ||||
| Coronary artery | HCAEC | 6 | 6.7 | 0-18.2 |
| Tissue . | EC Sample . | No. of Experiments* . | Mean %A0 . | Range for %A0† . |
|---|---|---|---|---|
| Microvascular EC | ||||
| Lung | HMVEC-LU | 16 | 3.5 | 0-14.5 |
| Liver | HMVEC-H | 9 | 5.8 | 0-18.1 |
| Dermal | MVEC-1, -2 | 4 | 37.3 | 15.2-50.4 |
| Brain | HMVEC-B | 7 | 11.3 | 1.0-20.7 |
| Kidney | HMVEC-G | 5 (no renal disease)‡ | 9.2 | 0-15.5 |
| 3 (renal disease)‡ | 17.4 | 9.7-36.3 | ||
| Large vessel | ||||
| Coronary artery | HCAEC | 6 | 6.7 | 0-18.2 |
All plasmas used at a 1% final concentration.
Control values, representing EC incubated for 18 hours in 1% normal plasma, were less than 10% and have been subtracted from these numbers.
A minimum of three different TTP plasma samples were used for each tissue type.
Pertains to plasmas obtained from acute TTP patients with and without clinical renal involvement.