Single-Dose MTD of G28-5 sFv-PE40 in SCID Mice
| . | No. of Survivors . | ||||
|---|---|---|---|---|---|
| . | 0.16 mg/kg . | 0.32 mg/kg . | 0.48 mg/kg . | 0.65 mg/kg . | 0.81 mg/kg . |
| G28-5 sFv-PE40 | 3/3 | 3/3 | 3/3 | 0/3 | 0/3 |
| BR96 sFv-PE40 | 3/3 | 3/3 | 2/3 | 0/3 | 0/3 |
| . | No. of Survivors . | ||||
|---|---|---|---|---|---|
| . | 0.16 mg/kg . | 0.32 mg/kg . | 0.48 mg/kg . | 0.65 mg/kg . | 0.81 mg/kg . |
| G28-5 sFv-PE40 | 3/3 | 3/3 | 3/3 | 0/3 | 0/3 |
| BR96 sFv-PE40 | 3/3 | 3/3 | 2/3 | 0/3 | 0/3 |
Groups of three 6- to 8-week-old female C.B.-17 SCID mice were injected with the indicated concentrations of immunotoxin. The mice were observed daily for 7 days.