R and S Mutations in Myeloma VL Genes
| Patient . | Ig Class . | Germline Gene . | R:S (CDR)obs R:S (FWR)obs . | R (CDR)exp R (FWR)exp . | P (CDR)* P (FWR) . |
|---|---|---|---|---|---|
| 1 | IgGκ | 08/18 | 4.00 (4:1) | 4 | .22 |
| 0.63 (5:8) | 10 | .02 | |||
| 2 | IgGκ | 08/18 | 1.70 (5:3) | 4 | .14 |
| 3.00 (6:2) | 9 | .09 | |||
| 3 | IgGκ | 08/18 | 1.50 (3:2) | 3 | .26 |
| 0.80 (4:5) | 8 | .03 | |||
| 4 | IgGκ | 08/18 | 0.50 (2:4) | 3 | .20 |
| 0.60 (3:5) | 8 | .01 | |||
| 5 | IgGκ | A30 | 5.00 (5:0) | 3 | .09 |
| 1.00 (4:4) | 7 | .19 | |||
| 6 | IgGκ | A27 | 1.50 (6:4) | 4 | .12 |
| 3.00 (6:2) | 10 | .16 | |||
| 7 | IgGκ | A27 | 3.00 (6:2) | 3 | .03 |
| 4.00 (4:1) | 7 | .06 | |||
| 8 | IgAκ | A27 | ∞ (11.0) | 3 | .0001 |
| 4.00 (4:1) | 8 | .02 | |||
| 9 | IgGκ | L6 | ∞ (3:0) | 1 | .04 |
| 0.00 (0:1) | 2 | .00 | |||
| 10 | IgGλ | DPL2 | 2.00 (4:2) | 3 | .20 |
| 1.00 (3:3) | 6 | .06 | |||
| 11 | IgGλ | DPL3 | 1.50 (9:6) | 6 | .08 |
| 0.50 (3:6) | 12 | .0002 | |||
| 12 | IgGλ | IGLV3S2 | 6.00 (6:1) | 2 | .006 |
| 0.00 (0:2) | 0 | .00 | |||
| 13 | IgGλ | DPL11 | 5.00 (5:0) | 3 | .08 |
| 0.50 (2:4) | 6 | .03 | |||
| 14 | IgAλ | HSLV2046 | 3.00 (6:2) | 4 | .09 |
| 1.33 (4:3) | 8 | .04 | |||
| 15 | IgGλ | DPL23 | 3.50 (7:2) | 4 | .14 |
| 0.50 (3:6) | 10 | .0012 |
| Patient . | Ig Class . | Germline Gene . | R:S (CDR)obs R:S (FWR)obs . | R (CDR)exp R (FWR)exp . | P (CDR)* P (FWR) . |
|---|---|---|---|---|---|
| 1 | IgGκ | 08/18 | 4.00 (4:1) | 4 | .22 |
| 0.63 (5:8) | 10 | .02 | |||
| 2 | IgGκ | 08/18 | 1.70 (5:3) | 4 | .14 |
| 3.00 (6:2) | 9 | .09 | |||
| 3 | IgGκ | 08/18 | 1.50 (3:2) | 3 | .26 |
| 0.80 (4:5) | 8 | .03 | |||
| 4 | IgGκ | 08/18 | 0.50 (2:4) | 3 | .20 |
| 0.60 (3:5) | 8 | .01 | |||
| 5 | IgGκ | A30 | 5.00 (5:0) | 3 | .09 |
| 1.00 (4:4) | 7 | .19 | |||
| 6 | IgGκ | A27 | 1.50 (6:4) | 4 | .12 |
| 3.00 (6:2) | 10 | .16 | |||
| 7 | IgGκ | A27 | 3.00 (6:2) | 3 | .03 |
| 4.00 (4:1) | 7 | .06 | |||
| 8 | IgAκ | A27 | ∞ (11.0) | 3 | .0001 |
| 4.00 (4:1) | 8 | .02 | |||
| 9 | IgGκ | L6 | ∞ (3:0) | 1 | .04 |
| 0.00 (0:1) | 2 | .00 | |||
| 10 | IgGλ | DPL2 | 2.00 (4:2) | 3 | .20 |
| 1.00 (3:3) | 6 | .06 | |||
| 11 | IgGλ | DPL3 | 1.50 (9:6) | 6 | .08 |
| 0.50 (3:6) | 12 | .0002 | |||
| 12 | IgGλ | IGLV3S2 | 6.00 (6:1) | 2 | .006 |
| 0.00 (0:2) | 0 | .00 | |||
| 13 | IgGλ | DPL11 | 5.00 (5:0) | 3 | .08 |
| 0.50 (2:4) | 6 | .03 | |||
| 14 | IgAλ | HSLV2046 | 3.00 (6:2) | 4 | .09 |
| 1.33 (4:3) | 8 | .04 | |||
| 15 | IgGλ | DPL23 | 3.50 (7:2) | 4 | .14 |
| 0.50 (3:6) | 10 | .0012 |
Probability calculations according to Chang and Casali.17