Effects of TNFR:Fc in Normal Subjects
| Time . | TAT Complexes . | PAP Complexes . | Soluble E-Selectin . | Secretory PLA2 . | Neutrophils . | Elastase-α1-Antitrypsin . | IL-6 (pg/mL) . |
|---|---|---|---|---|---|---|---|
| (hr) . | (ng/mL) . | (nmol/L) . | (ng/mL) . | (ng/mL) . | (×109/L) . | Complexes (ng/mL) . | . |
| Pre | 6.4 ± 0.9 | 4.1 ± 0.3 | 13.3 ± 3.1 | 2.38 ± 0.54 | 1.91 ± 0.65 | <40 | <4 |
| 2 | 5.9 ± 0.8 | 4.6 ± 0.9 | 13.8 ± 2.8 | 1.97 ± 0.45 | 2.14 ± 0.39 | <40 | <4 |
| 4 | 6.4 ± 1.9 | 5.6 ± 1.4 | 13.2 ± 2.5 | 1.82 ± 0.39 | 3.25 ± 0.62 | <40 | <4 |
| 6 | 7.3 ± 2.4 | 5.5 ± 0.6 | 13.5 ± 2.7 | 1.73 ± 0.33 | 3.31 ± 0.45 | <40 | <4 |
| 12 | 2.4 ± 0.2 | 6.8 ± 0.9 | 13.7 ± 2.8 | 1.60 ± 0.32 | 2.78 ± 0.24 | <40 | <4 |
| 24 | 2.0 ± 0.2 | 4.4 ± 0.7 | 12.6 ± 2.5 | 1.83 ± 0.27 | 2.16 ± 0.30 | <40 | <4 |
| Time . | TAT Complexes . | PAP Complexes . | Soluble E-Selectin . | Secretory PLA2 . | Neutrophils . | Elastase-α1-Antitrypsin . | IL-6 (pg/mL) . |
|---|---|---|---|---|---|---|---|
| (hr) . | (ng/mL) . | (nmol/L) . | (ng/mL) . | (ng/mL) . | (×109/L) . | Complexes (ng/mL) . | . |
| Pre | 6.4 ± 0.9 | 4.1 ± 0.3 | 13.3 ± 3.1 | 2.38 ± 0.54 | 1.91 ± 0.65 | <40 | <4 |
| 2 | 5.9 ± 0.8 | 4.6 ± 0.9 | 13.8 ± 2.8 | 1.97 ± 0.45 | 2.14 ± 0.39 | <40 | <4 |
| 4 | 6.4 ± 1.9 | 5.6 ± 1.4 | 13.2 ± 2.5 | 1.82 ± 0.39 | 3.25 ± 0.62 | <40 | <4 |
| 6 | 7.3 ± 2.4 | 5.5 ± 0.6 | 13.5 ± 2.7 | 1.73 ± 0.33 | 3.31 ± 0.45 | <40 | <4 |
| 12 | 2.4 ± 0.2 | 6.8 ± 0.9 | 13.7 ± 2.8 | 1.60 ± 0.32 | 2.78 ± 0.24 | <40 | <4 |
| 24 | 2.0 ± 0.2 | 4.4 ± 0.7 | 12.6 ± 2.5 | 1.83 ± 0.27 | 2.16 ± 0.30 | <40 | <4 |
TNFR:Fc (6 mg/m2) was infused for 30 minutes. Data are the mean ± SE of 6 normal subjects obtained before the start of the infusion (Pre) and at various time points after the end of the infusion.