Platelet transfusion increment
| . | Control . | Intervention . | P . |
|---|---|---|---|
| ITT analysis | |||
| Platelet transfusions, n | 1568 | 1659 | |
| Efficacy parameters, mean ± SD | |||
| Count increment 1 h, 109/L | 25 ± 14 (n = 848) | 13 ± 8 (n = 997) | |
| CCI 1 h | 13 ± 7 (n = 848) | 8 ± 5 (n =9 97) | <.001 |
| Count increment 24 h, 109/L | 14 ± 14 (n = 953) | 8 ± 9 (n = 1007) | |
| CCI 24 h | 7 ± 7 (n = 953) | 4 ± 4 (n = 1007) | <.001 |
| Transfusion failure rate, median (IQR) | |||
| CCI 1 h, <7.5 | 0 (0-0.08) | 0.50 (0.09-0.75) | <.001 |
| CCI 24 h, <4.5 | 0 (0-0.33) | 0.50 (0.20-0.83) | <.001 |
| CCI 24 h, ≤0 | 0 (0-0) | 0 (0-0.08) | .013 |
| Per-protocol analysis | |||
| Platelet transfusions, n | 1395 | 1391 | |
| Efficacy parameters, mean ± SD | |||
| Count increment 1 h, 109/L | 25 ± 14 (n = 796) | 12 ± 8 (n = 868) | |
| CCI 1 h | 13 ± 7 (n = 796) | 7 ± 4 (n = 868) | <.001 |
| Count increment 24 h, 109/L | 14 ± 14 (n = 895) | 7 ± 8 (n = 897) | |
| CCI 24 h | 8 ± 7 (n = 895) | 4 ± 4 (n = 897) | <.001 |
| Transfusion failure rate, median (IQR) | |||
| CCI 1 h, <7.5 | 0 (0-0.02) | 0.50 (0.16-0.89) | <.001 |
| CCI 24 h, <4.5 | 0 (0-0.33) | 0.50 (0.18-0.93) | <.001 |
| CCI 24 h, ≤0 | 0 (0-0) | 0 (0-0.02) | .014 |
| . | Control . | Intervention . | P . |
|---|---|---|---|
| ITT analysis | |||
| Platelet transfusions, n | 1568 | 1659 | |
| Efficacy parameters, mean ± SD | |||
| Count increment 1 h, 109/L | 25 ± 14 (n = 848) | 13 ± 8 (n = 997) | |
| CCI 1 h | 13 ± 7 (n = 848) | 8 ± 5 (n =9 97) | <.001 |
| Count increment 24 h, 109/L | 14 ± 14 (n = 953) | 8 ± 9 (n = 1007) | |
| CCI 24 h | 7 ± 7 (n = 953) | 4 ± 4 (n = 1007) | <.001 |
| Transfusion failure rate, median (IQR) | |||
| CCI 1 h, <7.5 | 0 (0-0.08) | 0.50 (0.09-0.75) | <.001 |
| CCI 24 h, <4.5 | 0 (0-0.33) | 0.50 (0.20-0.83) | <.001 |
| CCI 24 h, ≤0 | 0 (0-0) | 0 (0-0.08) | .013 |
| Per-protocol analysis | |||
| Platelet transfusions, n | 1395 | 1391 | |
| Efficacy parameters, mean ± SD | |||
| Count increment 1 h, 109/L | 25 ± 14 (n = 796) | 12 ± 8 (n = 868) | |
| CCI 1 h | 13 ± 7 (n = 796) | 7 ± 4 (n = 868) | <.001 |
| Count increment 24 h, 109/L | 14 ± 14 (n = 895) | 7 ± 8 (n = 897) | |
| CCI 24 h | 8 ± 7 (n = 895) | 4 ± 4 (n = 897) | <.001 |
| Transfusion failure rate, median (IQR) | |||
| CCI 1 h, <7.5 | 0 (0-0.02) | 0.50 (0.16-0.89) | <.001 |
| CCI 24 h, <4.5 | 0 (0-0.33) | 0.50 (0.18-0.93) | <.001 |
| CCI 24 h, ≤0 | 0 (0-0) | 0 (0-0.02) | .014 |
IQR, interquartile range.