Analysis of the Distribution of Somatic Mutations
| Patient No. . | Germ Line . | CDR/FWR . | Calculated R:S . | Observed . | P* . | ||
|---|---|---|---|---|---|---|---|
| . | . | . | . | R . | S . | R:S . | . |
| 11 | V1-69 | CDR | 3.4 | 5 | 3 | 1.7 | .16 |
| FWR | 3.0 | 8 | 5 | 1.6 | .04 | ||
| 12 | V1-2 | CDR | 4.3 | 7 | 0 | ∞ | .06 |
| FWR | 3.0 | 8 | 7 | 1.1 | .02 | ||
| 13 | V3-30.3 | CDR | 3.9 | 8 | 0 | ∞ | <.01 |
| FWR | 2.9 | 4 | 2 | 2.0 | .02 | ||
| 14 | V1-3 | CDR | 4.3 | 0 | 0 | ∞ | .45 |
| FWR | 3.0 | 3 | 1 | 3.0 | .33 | ||
| 15 | V1-2 | CDR | 4.3 | 4 | 3 | 1.3 | .21 |
| FWR | 3.0 | 12 | 4 | 3.0 | .14 | ||
| 16 | V3-23 | CDR | 3.5 | 8 | 2 | 4.0 | .03 |
| FWR | 2.9 | 6 | 8 | 0.8 | <.01 | ||
| 17 | V4-34 | CDR | 4.4 | 3 | 4 | 0.8 | .24 |
| FWR | 2.8 | 8 | 3 | 2.7 | .10 | ||
| 18 | V3-48 | CDR | 4.7 | 4 | 0 | ∞ | .10 |
| FWR | 2.8 | 5 | 2 | 2.5 | .18 | ||
| 21 | V4-34 | CDR | 4.4 | 3 | 0 | ∞ | .25 |
| FWR | 2.8 | 11 | 2 | 5.5 | .14 | ||
| 22 | V3-30 | CDR | 3.9 | 15 | 1 | 15.0 | <.01 |
| FWR | 2.9 | 9 | 4 | 2.3 | .01 | ||
| Patient No. . | Germ Line . | CDR/FWR . | Calculated R:S . | Observed . | P* . | ||
|---|---|---|---|---|---|---|---|
| . | . | . | . | R . | S . | R:S . | . |
| 11 | V1-69 | CDR | 3.4 | 5 | 3 | 1.7 | .16 |
| FWR | 3.0 | 8 | 5 | 1.6 | .04 | ||
| 12 | V1-2 | CDR | 4.3 | 7 | 0 | ∞ | .06 |
| FWR | 3.0 | 8 | 7 | 1.1 | .02 | ||
| 13 | V3-30.3 | CDR | 3.9 | 8 | 0 | ∞ | <.01 |
| FWR | 2.9 | 4 | 2 | 2.0 | .02 | ||
| 14 | V1-3 | CDR | 4.3 | 0 | 0 | ∞ | .45 |
| FWR | 3.0 | 3 | 1 | 3.0 | .33 | ||
| 15 | V1-2 | CDR | 4.3 | 4 | 3 | 1.3 | .21 |
| FWR | 3.0 | 12 | 4 | 3.0 | .14 | ||
| 16 | V3-23 | CDR | 3.5 | 8 | 2 | 4.0 | .03 |
| FWR | 2.9 | 6 | 8 | 0.8 | <.01 | ||
| 17 | V4-34 | CDR | 4.4 | 3 | 4 | 0.8 | .24 |
| FWR | 2.8 | 8 | 3 | 2.7 | .10 | ||
| 18 | V3-48 | CDR | 4.7 | 4 | 0 | ∞ | .10 |
| FWR | 2.8 | 5 | 2 | 2.5 | .18 | ||
| 21 | V4-34 | CDR | 4.4 | 3 | 0 | ∞ | .25 |
| FWR | 2.8 | 11 | 2 | 5.5 | .14 | ||
| 22 | V3-30 | CDR | 3.9 | 15 | 1 | 15.0 | <.01 |
| FWR | 2.9 | 9 | 4 | 2.3 | .01 | ||
Values in boldface type reach significance (P < .05). Underlined values indicate significant clustering in CDRs.
Abbreviation: P, probability of obtaining the number of R mutations found in CDRs by chance.