Clinical Details of Patients From Whom Tissues Were Obtained
| Tissue Type . | Platelet Count and Other Clinical Details . |
|---|---|
| BM trephines | |
| (a) Normal platelet count with normocellular marrow | |
| Platelet count = 230 ± 45 × 109/L (mean ± SD) | |
| Stage 1 or 2 Non-hodgkin's lymphoma (n = 3) | |
| Stomach carcinoma for staging (n = 1) | |
| Splenomegaly due to subacute endocarditis (n = 1) | |
| (b) Thrombocytopenia — hypoplastic marrow | |
| Platelet count = 26 ± 15 × 109/L (mean ± SD) | |
| Severe aplastic anemia (n = 4) | |
| Postchemotherapy BM aplasia (n = 3) | |
| (c) Thrombocytopenia — normocellular marrow with increased megakaryocytes | |
| Platelet count = 33 ± 25 × 109/L (mean ± SD) | |
| ITP (n = 5) | |
| Immune thrombocytopenia secondary to Hodgkin's disease (n = 1) | |
| (d) Thrombocytosis | |
| Platelet count = 993 × 109/L (mean) | |
| Thrombocytosis secondary to an inflammatory myosarcoma of the mesentery (n = 1) | |
| Thrombocytosis due to sepsis (n = 1) | |
| Liver and Spleen | (a) Normal platelet counts with normal liver and spleen functions |
| Platelet count = 232 ± 109 × 109/L (mean ± SD) | |
| Liver resection due to liver metastatic cancer but normal parts of the tissue were used in the study (n = 3) | |
| Spleen removed because of traumatic tear from stab wound (n = 1) | |
| Spleen removed from ITP patient after platelet count had been normalized for 2 wk (n = 1) | |
| (b) Thrombocytopenia | |
| Platelet count = 64 ± 36 × 109/L (mean ± SD) | |
| ITP (n = 2) | |
| Immune thrombocytopenia secondary to Hodgkin's disease (n = 1) | |
| Liver biopsies were performed during splenectomy (n = 2) | |
| Kidney | (a) Normocellular kidney with normal platelet count |
| Platelet count = 289 ± 71 × 109/L (mean ± SD) | |
| Kidneys were removed because of renal cell carcinoma but normal parts of the tissue were used for the study (n = 5) | |
| (b) Thrombocytopenia | |
| Platelet count = 70 × 109/L (mean) | |
| Renal biopsy was performed because of systemic lupus erythematosus (n = 1) and proteinuria (n = 1) | |
| Although some glomeruli were affected by the underlying disease the renal tubules were essentially normal |
| Tissue Type . | Platelet Count and Other Clinical Details . |
|---|---|
| BM trephines | |
| (a) Normal platelet count with normocellular marrow | |
| Platelet count = 230 ± 45 × 109/L (mean ± SD) | |
| Stage 1 or 2 Non-hodgkin's lymphoma (n = 3) | |
| Stomach carcinoma for staging (n = 1) | |
| Splenomegaly due to subacute endocarditis (n = 1) | |
| (b) Thrombocytopenia — hypoplastic marrow | |
| Platelet count = 26 ± 15 × 109/L (mean ± SD) | |
| Severe aplastic anemia (n = 4) | |
| Postchemotherapy BM aplasia (n = 3) | |
| (c) Thrombocytopenia — normocellular marrow with increased megakaryocytes | |
| Platelet count = 33 ± 25 × 109/L (mean ± SD) | |
| ITP (n = 5) | |
| Immune thrombocytopenia secondary to Hodgkin's disease (n = 1) | |
| (d) Thrombocytosis | |
| Platelet count = 993 × 109/L (mean) | |
| Thrombocytosis secondary to an inflammatory myosarcoma of the mesentery (n = 1) | |
| Thrombocytosis due to sepsis (n = 1) | |
| Liver and Spleen | (a) Normal platelet counts with normal liver and spleen functions |
| Platelet count = 232 ± 109 × 109/L (mean ± SD) | |
| Liver resection due to liver metastatic cancer but normal parts of the tissue were used in the study (n = 3) | |
| Spleen removed because of traumatic tear from stab wound (n = 1) | |
| Spleen removed from ITP patient after platelet count had been normalized for 2 wk (n = 1) | |
| (b) Thrombocytopenia | |
| Platelet count = 64 ± 36 × 109/L (mean ± SD) | |
| ITP (n = 2) | |
| Immune thrombocytopenia secondary to Hodgkin's disease (n = 1) | |
| Liver biopsies were performed during splenectomy (n = 2) | |
| Kidney | (a) Normocellular kidney with normal platelet count |
| Platelet count = 289 ± 71 × 109/L (mean ± SD) | |
| Kidneys were removed because of renal cell carcinoma but normal parts of the tissue were used for the study (n = 5) | |
| (b) Thrombocytopenia | |
| Platelet count = 70 × 109/L (mean) | |
| Renal biopsy was performed because of systemic lupus erythematosus (n = 1) and proteinuria (n = 1) | |
| Although some glomeruli were affected by the underlying disease the renal tubules were essentially normal |